Entity Details

Primary name TBX21
Entity type gene
Source Source Link

Details

PrimaryID30009
RefseqGeneNG_012166
SymbolTBX21
NameT-box transcription factor 21
Chromosome17
Location17q21.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-29
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTBX21_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001708 cell fate specification
GO:0001947 heart looping
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007275 multicellular organism development
GO:0009615 response to virus
GO:0030217 T cell differentiation
GO:0032703 negative regulation of interleukin-2 production
GO:0043025 neuronal cell body
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043565 sequence-specific DNA binding
GO:0045580 regulation of T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0071310 cellular response to organic substance
GO:0072676 lymphocyte migration
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2000329 negative regulation of T-helper 17 cell lineage commitment
GO:2000552 negative regulation of T-helper 2 cell cytokine production

Diseases

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Disease IDSourceNameDescription
208550 OMIMAsthma, with nasal polyps and aspirin intolerance (ANPAI)A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

9 interactions

InteractorPartnerSourcesPublicationsLink
TBX21EXOC5BioGRID, IntAct21988832 details
TBX21HOXC11BioGRID, IntAct20211142 details
TBX21ZNF490BioGRID, IntAct20211142 details
TBX21EP300BioGRID, DIP17075044 details
TBX21GATA3BioGRID, DIP17075044 details
TBX21SP1BioGRID, DIP17075044 details
TBX21CREBBPBioGRID, DIP17075044 details
TBX21USP10BioGRID24845384 details
TBX21UBCBioGRID24845384 details