Entity Details

Primary name ETFD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16134
EntryNameETFD_HUMAN
FullNameElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length617
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesETFDH

GO terms

Show/Hide Table
GOName
GO:0004174 electron-transferring-flavoprotein dehydrogenase activity
GO:0005759 mitochondrial matrix
GO:0006979 response to oxidative stress
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0022900 electron transport chain
GO:0022904 respiratory electron transport chain
GO:0031305 integral component of mitochondrial inner membrane
GO:0031966 mitochondrial membrane
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0043783 oxidoreductase activity, acting on metal ions, flavin as acceptor
GO:0046872 metal ion binding
GO:0048038 quinone binding
GO:0048039 ubiquinone binding
GO:0050660 flavin adenine dinucleotide binding
GO:0051539 4 iron, 4 sulfur cluster binding

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion inner membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domainDomainDomain
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR040156 Electron transfer flavoprotein-ubiquinone oxidoreductaseFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
231680 OMIMGlutaric aciduria 2A (GA2A)An autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00331 MetforminDrugbanksmall molecule
DB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolDrugbanksmall molecule