Entity Details

Primary name SLC22A18
Entity type gene
Source Source Link

Details

PrimaryID5002
RefseqGeneNG_011512
SymbolSLC22A18
Namesolute carrier family 22 member 18
Chromosome11
Location11p15.4
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-08
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsS22AI_HUMAN

GO terms

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GOName
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0007588 excretion
GO:0015293 symporter activity
GO:0015695 organic cation transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0022857 transmembrane transporter activity
GO:0031625 ubiquitin protein ligase binding
GO:0042908 xenobiotic transport
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane

Diseases

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Disease IDSourceNameDescription
268210 OMIMRhabdomyosarcoma, embryonal, 1 (RMSE1)A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. The disease may be caused by variants affecting the gene represented in this entry.
211980 OMIMLung cancer (LNCR)A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. The gene represented in this entry may be involved in disease pathogenesis.
114480 OMIMBreast cancer (BC)A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
SLC22A18HSD17B11BioGRID, IntAct32296183 details
SLC22A18NKX3-1BioGRID, IntAct32296183 details
SLC22A18TLCD4BioGRID, IntAct32296183 details
SLC22A18TMX2BioGRID, IntAct32296183 details
SLC22A18RNF167BioGRID16314844 details
SLC22A18MMEBioGRID, IntAct28514442 details
SLC22A18SLC7A1BioGRID, IntAct28514442 details
SLC22A18SLC39A5BioGRID, IntAct28514442 details
SLC22A18HLA-DPA1BioGRID, IntAct26186194 28514442 details
SLC22A18C3AR1BioGRID, IntAct28514442 details
SLC22A18SLC39A4BioGRID, IntAct28514442 details
SLC22A18POMKBioGRID, IntAct28514442 details
SLC22A18CLEC2DBioGRID, IntAct28514442 details
SLC22A18GYPABioGRID, IntAct28514442 details
SLC22A18HAVCR2BioGRID, IntAct28514442 details
SLC22A18LAMP3BioGRID, IntAct28514442 details
SLC22A18TXNDC15BioGRID, IntAct28514442 details
SLC22A18SLC39A12BioGRID, IntAct28514442 details
SLC22A18NRG1BioGRID, IntAct26186194 28514442 details
SLC22A18MRAP2BioGRID, IntAct28514442 details
SLC22A18CA14BioGRID, IntAct26186194 28514442 details
SLC22A18SPACA1BioGRID, IntAct28514442 details
SLC22A18VSIG1BioGRID, IntAct28514442 details
SLC22A18CHST10BioGRID, IntAct28514442 details
SLC22A18ITM2ABioGRID, IntAct28514442 details
SLC22A18PMELBioGRID, IntAct28514442 details
SLC22A18SLC39A8BioGRID, IntAct28514442 details
SLC22A18AMIGO3BioGRID, IntAct28514442 details
SLC22A18KITLGBioGRID, IntAct28514442 details
SLC22A18ECI2BioGRID, IntAct30021884 details
SLC22A18HLA-DQA1BioGRID28514442 details
SLC22A18RNF4BioGRID29180619 details