Entity Details

Primary name APH1A
Entity type gene
Source Source Link

Details

PrimaryID51107
RefseqGeneNG_029952
SymbolAPH1A
Nameaph-1 homolog A, gamma-secretase subunit
Chromosome1
Location1q21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-11
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsAPH1A_HUMAN

GO terms

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GOName
GO:0001656 metanephros development
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006509 membrane protein ectodomain proteolysis
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0008021 synaptic vesicle
GO:0010008 endosome membrane
GO:0010950 positive regulation of endopeptidase activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0019899 enzyme binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032580 Golgi cisterna membrane
GO:0034205 amyloid-beta formation
GO:0035333 Notch receptor processing, ligand-dependent
GO:0042982 amyloid precursor protein metabolic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0048013 ephrin receptor signaling pathway
GO:0061133 endopeptidase activator activity
GO:0070765 gamma-secretase complex
GO:0099056 integral component of presynaptic membrane
GO:1990000 amyloid fibril formation

Diseases

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Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
APH1ACREB3BioGRID, MINT21516116 details
APH1AATF4BioGRID, IntAct21988832 details
APH1AHIVEP1BioGRID, IntAct21988832 details
APH1AHES1BioGRID, IntAct21988832 details
APH1ATHPOBioGRID, IntAct21988832 details
APH1ATLE1BioGRID, IntAct21988832 details
APH1AKLF11BioGRID, IntAct21988832 details
APH1ABHLHE40BioGRID, IntAct21988832 details
APH1AGPATCH8BioGRID, IntAct21988832 details
APH1ARBFOX2BioGRID, IntAct21988832 details
APH1AMPP1BioGRID, IntAct32296183 details
APH1ATMEM140BioGRID, IntAct32296183 details
APH1ATMEM218BioGRID, IntAct32296183 details
APH1AASGR1BioGRID, IntAct32296183 details
APH1ASLC39A9BioGRID, IntAct32296183 details
APH1AIGFBP5BioGRID, IntAct32296183 details
APH1AMRAP2BioGRID, IntAct32296183 details
APH1ASMAGPBioGRID, IntAct32296183 details
APH1AFIS1BioGRID, IntAct32296183 details
APH1ASCAND1BioGRID, IntAct32296183 details
APH1AMFSD6BioGRID, IntAct32296183 details
APH1AANKRD46BioGRID, IntAct32296183 details
APH1AAPODBioGRID, IntAct32296183 details
APH1ALATBioGRID, IntAct32296183 details
APH1ASLC38A7BioGRID, IntAct32296183 details
APH1ASERP1BioGRID, IntAct32296183 details
APH1AFXYD6BioGRID, IntAct32296183 details
APH1ADRD2BioGRID, MINT28298427 details
APH1AGPR35BioGRID, MINT28298427 details
APH1AACTR3IntAct32814053 details
APH1ACYTH1IntAct32814053 details
APH1AFYNIntAct32814053 details
APH1AAPPIntAct32814053 details
APH1AGLP1RBioGRID23864651 details
APH1ATRARG1BioGRID32296183 details
APH1ANCSTNBioGRID, DIP, HPRD, IntAct, MINT12297508 12471034 12857757 14572442 15257293 15474363 17911105 18201567 18667537 19376115 26280335 details
APH1APSENENBioGRID, DIP, HPRD, MINT12740439 14572442 15322109 15474363 17911105 18667537 19376115 22074918 26280335 details
APH1APSEN1BioGRID, DIP, HPRD, UniProt12297508 12471034 14572442 15474363 17911105 18667537 26280335 30559186 details
APH1APSEN2BioGRID, HPRD12297508 12471034 15474363 details
APH1AAPH1ABioGRID15474363 details
APH1AERLIN2BioGRID22771797 details
APH1ATMED10HPRD16641999 details
APH1AADAM10UniProt30538620 details
APH1ALMBR1LBioGRID31073040 details
APH1AELAVL1BioGRID19322201 details
APH1AMOV10BioGRID22658674 details
APH1ANXF1BioGRID22658674 details
APH1AHNRNPH1BioGRID26760575 details
APH1ADDX58BioGRID32513696 details