Entity Details

Primary name DAA11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86X45
EntryNameDAA11_HUMAN
FullNameDynein axonemal assembly factor 11
TaxID9606
Evidenceevidence at protein level
Length466
SequenceStatuscomplete
DateCreated2005-10-11
DateModified2021-06-02

Ontological Relatives

GenesDNAAF11

GO terms

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GOName
GO:0003341 cilium movement
GO:0003351 epithelial cilium movement involved in extracellular fluid movement
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005929 cilium
GO:0008584 male gonad development
GO:0030317 flagellated sperm motility
GO:0036158 outer dynein arm assembly
GO:0036159 inner dynein arm assembly
GO:0043393 regulation of protein binding
GO:0044458 motile cilium assembly
GO:0051649 establishment of localization in cell
GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry
GO:0061458 reproductive system development
GO:0061512 protein localization to cilium
GO:0070286 axonemal dynein complex assembly
GO:0090651 apical cytoplasm
GO:0090660 cerebrospinal fluid circulation
GO:0120229 protein localization to motile cilium
GO:0120293 dynein axonemal particle

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Dynein axonemal particle

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003603 U2A'/phosphoprotein 32 family A, C-terminalDomainDomain
IPR007052 CS domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614935 OMIMCiliary dyskinesia, primary, 19 (CILD19)A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. The disease is caused by variants affecting the gene represented in this entry.