Entity Details

Primary name SC5A5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92911
EntryNameSC5A5_HUMAN
FullNameSodium/iodide cotransporter
TaxID9606
Evidenceevidence at protein level
Length643
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesSLC5A5

GO terms

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GOName
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0006590 thyroid hormone generation
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0008507 sodium:iodide symporter activity
GO:0015111 iodide transmembrane transporter activity
GO:0015293 symporter activity
GO:0015705 iodide transport
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
GO:0150104 transport across blood-brain barrier
GO:1903561 extracellular vesicle
GO:1904200 iodide transmembrane transport

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR001734 Sodium/solute symporterFamilyFamily
IPR018212 Sodium/solute symporter, conserved siteSiteConserved site
IPR035689 Sodium/iodide cotransporterFamilyFamily
IPR038377 Sodium/glucose symporter superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
274400 OMIMThyroid dyshormonogenesis 1 (TDH1)A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB05382 IodineDrugbanksmall molecule
DB09418 Potassium perchlorateDrugbanksmall molecule