Entity Details

Primary name SMG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96Q15
EntryNameSMG1_HUMAN
FullNameSerine/threonine-protein kinase SMG1
TaxID9606
Evidenceevidence at protein level
Length3661
SequenceStatuscomplete
DateCreated2006-04-04
DateModified2021-06-02

Ontological Relatives

GenesSMG1

GO terms

Show/Hide Table
GOName
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003723 RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006406 mRNA export from nucleus
GO:0016242 negative regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0031931 TORC1 complex
GO:0031932 TORC2 complex
GO:0032204 regulation of telomere maintenance
GO:0038202 TORC1 signaling
GO:0042162 telomeric DNA binding
GO:0046777 protein autophosphorylation
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2001020 regulation of response to DNA damage stimulus

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003152 FATC domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014009 PIK-related kinaseDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR031559 Serine/threonine-protein kinase SMG1FamilyFamily
IPR035175 Serine/threonine-protein kinase SMG1, N-terminalDomainDomain
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR039414 SMG1, PIKK catalytic domainDomainDomain

Diseases

Show/Hide Table

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
SMG1_HUMANRENT2_HUMANBioGRID, HPRD, MINT, UniProt11544179 16452507 18256688 19417104 20371770 details
SMG1_HUMANRENT1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11331269 11544179 16452507 18256688 18423202 19417104 20371770 details
SMG1_HUMANSMG8_HUMANBioGRID, UniProt19417104 20371770 20817927 details
SMG1_HUMANSMG9_HUMANBioGRID, IntAct, UniProt19417104 20371770 20817927 26496610 details
SMG1_HUMANSNAPN_HUMANBioGRID, IntAct23414517 details
SMG1_HUMANKPCI_HUMANBioGRID, HPRD8524286 details
SMG1_HUMANSMG1_HUMANBioGRID11544179 details
SMG1_HUMANSMAD9_HUMANHPRD15231748 details
SMG1_HUMANIF4A2_HUMANBioGRID, IntAct17353931 29395067 details
SMG1_HUMANTELO2_HUMANBioGRID, IntAct18160036 20427287 details
SMG1_HUMANREN3A_HUMANBioGRID, HPRD, MINT, UniProt11544179 16452507 18256688 details
SMG1_HUMANSMG7_HUMANBioGRID, UniProt16452507 29395067 31732746 details
SMG1_HUMANPABP1_HUMANBioGRID, UniProt16452507 details
SMG1_HUMANREN3B_HUMANBioGRID, UniProt16452507 18256688 details
SMG1_HUMANTTI1_HUMANBioGRID, UniProt20371770 20427287 20810650 details
SMG1_HUMANDISC1_HUMANIntAct31413325 details
SMG1_HUMANNDEL1_HUMANIntAct31413325 details
SMG1_HUMANERF3A_HUMANBioGRID16452507 details
SMG1_HUMANHS90A_HUMANBioGRID20371770 details
SMG1_HUMANHSP74_HUMANBioGRID20371770 details
SMG1_HUMANTBA1A_HUMANBioGRID20371770 details
SMG1_HUMANTBG1_HUMANBioGRID20371770 details
SMG1_HUMANZ3H7A_HUMANBioGRID29395067 30995489 details
SMG1_HUMANFMR1_HUMANBioGRID29395067 details
SMG1_HUMANMEX3B_HUMANBioGRID29395067 details
SMG1_HUMANMKRN2_HUMANBioGRID29395067 details
SMG1_HUMANMOV10_HUMANBioGRID29395067 details
SMG1_HUMANPRC2A_HUMANBioGRID29395067 details
SMG1_HUMANRN214_HUMANBioGRID29395067 details
SMG1_HUMANEST1A_HUMANBioGRID29395067 details
SMG1_HUMANTDRD3_HUMANBioGRID29395067 details
SMG1_HUMANUNK_HUMANBioGRID29395067 details
SMG1_HUMANYTHD2_HUMANBioGRID29395067 details
SMG1_HUMANYTHD3_HUMANBioGRID29395067 details
SMG1_HUMANFXR2_HUMANBioGRID29395067 details
SMG1_HUMANIF2B1_HUMANBioGRID29395067 details
SMG1_HUMANZCCHV_HUMANBioGRID29395067 details
SMG1_HUMANLIN41_HUMANBioGRID31732746 details
SMG1_HUMANCADH5_HUMANHPRD10428027 details
SMG1_HUMANSMG5_HUMANHPRD14636577 details