Entity Details

Primary name CARD9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H257
EntryNameCARD9_HUMAN
FullNameCaspase recruitment domain-containing protein 9
TaxID9606
Evidenceevidence at protein level
Length536
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesCARD9

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009620 response to fungus
GO:0032494 response to peptidoglycan
GO:0032495 response to muramyl dipeptide
GO:0032663 regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032991 protein-containing complex
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0050700 CARD domain binding
GO:0050830 defense response to Gram-positive bacterium
GO:0051607 defense response to virus

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR042142 CARD9, CARD domainDomainDomain

Diseases

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Disease IDSourceNameDescription
212050 OMIMCandidiasis, familial, 2 (CANDF2)A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. The disease is caused by variants affecting the gene represented in this entry. Defects induce reduced numbers of CD4(+) Th17 lymphocytes as well as a lack of monocyte-derived cytokines in response to Candida strains (PubMed:23335372). Neutrophils show a selective Candida albicans killing defect with abnormal ultrastructural phagolysosomes and outgrowth of hyphae (PubMed:23335372).

Interactions

147 interactions

InteractorPartnerSourcesPublicationsLink
CARD9_HUMANCC85B_HUMANBioGRID, HPRD, IntAct16189514 details
CARD9_HUMANK0408_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
CARD9_HUMANBCL10_HUMANBioGRID, HPRD, InnateDB, IntAct11053425 22267217 25416956 28765954 details
CARD9_HUMANZN572_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CARD9_HUMANC19L2_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANIF4E2_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANZN250_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANRBTN1_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANMFAP1_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANTCL1A_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANTRI29_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANRTP5_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANF161A_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CARD9_HUMANC2CD6_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANPPR18_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CARD9_HUMANZN655_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANTEANC_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANZN417_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANCCHCR_HUMANBioGRID, IntAct25416956 29892012 details
CARD9_HUMANLENG1_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANZN587_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANTSNAX_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANTRI42_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANMEOX2_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANK1C19_HUMANBioGRID, IntAct25416956 31515488 details
CARD9_HUMANSTX11_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANNECA2_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANABLM1_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANTLE5_HUMANBioGRID, IntAct25416956 31515488 details
CARD9_HUMANSUMO1_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANTRI23_HUMANBioGRID, IntAct25416956 31515488 details
CARD9_HUMANPBX2_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANKR105_HUMANIntAct25416956 details
CARD9_HUMANCA094_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANHMBX1_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANBACD2_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANTASO2_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANZCHC7_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANCE57L_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANKCTD9_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANPHC2_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANIHO1_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANPNMA5_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANCEP70_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANPAK5_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CARD9_HUMANCDA7L_HUMANBioGRID, IntAct25416956 29892012 details
CARD9_HUMANLZTS2_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANADIP_HUMANBioGRID, IntAct25416956 27107012 details
CARD9_HUMANTRI54_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANGO45_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANTFP11_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANAMOL2_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANF124B_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANDAXX_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANDS13B_HUMANBioGRID, IntAct25416956 32296183 details
CARD9_HUMANFA50B_HUMANBioGRID, IntAct25416956 details
CARD9_HUMANUBP15_HUMANBioGRID, IntAct25416956 31515488 33093067 details
CARD9_HUMANCARD9_HUMANBioGRID, HPRD, IntAct11053425 25416956 32296183 details
CARD9_HUMANIQCE_HUMANBioGRID, IntAct24722188 details
CARD9_HUMANVPS28_HUMANBioGRID, IntAct25416956 26871637 details
CARD9_HUMANAXIN1_HUMANBioGRID, IntAct26871637 details
CARD9_HUMANDVL2_HUMANBioGRID, IntAct27107012 details
CARD9_HUMANZBT16_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANTRI14_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANSAXO1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANIKZF3_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANT10IP_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANK1328_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANK1C15_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANLMBL2_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANLMO3_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZGPAT_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANCABP2_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANLZTS1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANKANK2_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANKIFC3_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANK2C75_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANF90A1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANPRP18_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANHXB5_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANF161B_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANIF4A3_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZN121_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANMCRS1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANCRTP1_HUMANIntAct32296183 details
CARD9_HUMANCC120_HUMANIntAct32296183 details
CARD9_HUMANDDT4L_HUMANIntAct32296183 details
CARD9_HUMANSPAT6_HUMANIntAct32296183 details
CARD9_HUMANZN774_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZN224_HUMANIntAct32296183 details
CARD9_HUMANSTMN3_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANCCD13_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZMYM5_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANMT21D_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZN829_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZN620_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZN688_HUMANBioGRID, IntAct26871637 32296183 details
CARD9_HUMANSLAI1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANSHSA6_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANTENS4_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANUSH1G_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANCDC37_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANSCNM1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANCAR10_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANEFHC2_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANDRC4_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANTEX33_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANDISC1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANKRA57_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZC21C_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANK1C16_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANPSA4_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZZZ3_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANRBAK_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANCBX8_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANYES_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANGEM_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANCC88B_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANIN80B_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANUNKL_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANCDKA1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZN426_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANFX4L1_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZNF19_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANPKP2_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANZNF20_HUMANBioGRID, IntAct32296183 details
CARD9_HUMANKLK6_HUMANIntAct32814053 details
CARD9_HUMANVHL_HUMANBioGRID17936701 details
CARD9_HUMANCSK21_HUMANBioGRID17936701 details
CARD9_HUMANDS13A_HUMANBioGRID25416956 32296183 details
CARD9_HUMANKIF9_HUMANBioGRID25416956 details
CARD9_HUMANKR101_HUMANBioGRID25416956 details
CARD9_HUMANKR103_HUMANBioGRID25416956 details
CARD9_HUMANTRI62_HUMANBioGRID26488816 27779380 29073062 33093067 details
CARD9_HUMANPIBF1_HUMANBioGRID32296183 details
CARD9_HUMANUBC9_HUMANBioGRID32296183 details
CARD9_HUMANCC136_HUMANBioGRID32296183 details
CARD9_HUMANMY15B_HUMANBioGRID32296183 details