Entity Details

Primary name FOXP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H334
EntryNameFOXP1_HUMAN
FullNameForkhead box protein P1
TaxID9606
Evidenceevidence at protein level
Length677
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesFOXP1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001046 core promoter sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0002903 negative regulation of B cell apoptotic process
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0010468 regulation of gene expression
GO:0010595 positive regulation of endothelial cell migration
GO:0010629 negative regulation of gene expression
GO:0030316 osteoclast differentiation
GO:0032496 response to lipopolysaccharide
GO:0032651 regulation of interleukin-1 beta production
GO:0032655 regulation of interleukin-12 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032745 positive regulation of interleukin-21 production
GO:0035019 somatic stem cell population maintenance
GO:0036035 osteoclast development
GO:0042116 macrophage activation
GO:0042117 monocyte activation
GO:0042118 endothelial cell activation
GO:0043621 protein self-association
GO:0045655 regulation of monocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050681 androgen receptor binding
GO:0050727 regulation of inflammatory response
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0061470 T follicular helper cell differentiation
GO:1900424 regulation of defense response to bacterium
GO:1901256 regulation of macrophage colony-stimulating factor production
GO:1901509 regulation of endothelial tube morphogenesis
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032354 FOXP, coiled-coil domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
613670 OMIMMental retardation with language impairment and autistic features (MRLIAF)A developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors. The disease is caused by variants affecting the gene represented in this entry.