Entity Details

Primary name NDE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NXR1
EntryNameNDE1_HUMAN
FullNameNuclear distribution protein nudE homolog 1
TaxID9606
Evidenceevidence at protein level
Length335
SequenceStatuscomplete
DateCreated2006-06-13
DateModified2021-06-02

Ontological Relatives

GenesNDE1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000132 establishment of mitotic spindle orientation
GO:0000776 kinetochore
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0007020 microtubule nucleation
GO:0007052 mitotic spindle organization
GO:0007059 chromosome segregation
GO:0007100 mitotic centrosome separation
GO:0008017 microtubule binding
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0016477 cell migration
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0031616 spindle pole centrosome
GO:0032154 cleavage furrow
GO:0042802 identical protein binding
GO:0047496 vesicle transport along microtubule
GO:0051298 centrosome duplication
GO:0051301 cell division
GO:0051303 establishment of chromosome localization
GO:0051642 centrosome localization
GO:0097711 ciliary basal body-plasma membrane docking
GO:2000574 obsolete regulation of microtubule motor activity

Subcellular Location

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Subcellular Location
Chromosome
Cleavage furrow
Cytoplasm

Domains

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DomainNameCategoryType
IPR006964 NUDE domainDomainDomain
IPR033494 NUDE familyFamilyFamily

Diseases

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Disease IDSourceNameDescription
605013 OMIMMicrohydranencephaly (MHAC)A severe neurodevelopmental disorder characterized by microcephaly, severe motor and mental retardation, spasticity, and brain malformations that include gross dilation of the ventricles with complete absence of the cerebral hemispheres or severe delay in their development. The disease is caused by variants affecting the gene represented in this entry.
614019 OMIMLissencephaly 4 (LIS4)A neurodevelopmental disorder characterized by lissencephaly, severe brain atrophy, extreme microcephaly, and profound mental retardation. The disease is caused by variants affecting the gene represented in this entry.

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
NDE1_HUMANZN365_HUMANHPRD, IntAct16682949 details
NDE1_HUMANCDK1_HUMANHPRD, IntAct12556484 16682949 details
NDE1_HUMANNDE1_HUMANBioGRID, IntAct22843697 24722188 details
NDE1_HUMANNDEL1_HUMANBioGRID, IntAct22843697 24722188 28514442 details
NDE1_HUMANLIS1_HUMANBioGRID, HPRD, IntAct10931877 11163258 12885786 27173435 34079125 unassigned1312 details
NDE1_HUMANTRI27_HUMANBioGRID, IntAct24722188 26186194 28514442 details
NDE1_HUMANDISC1_HUMANBioGRID, IntAct, MINT24722188 29961565 31413325 details
NDE1_HUMAN1433T_HUMANBioGRID15161933 details
NDE1_HUMANANDR_HUMANBioGRID24722188 details
NDE1_HUMANARNT2_HUMANBioGRID24722188 details
NDE1_HUMANRIMB1_HUMANBioGRID24722188 details
NDE1_HUMANFAM9B_HUMANBioGRID24722188 details
NDE1_HUMANGOGA2_HUMANBioGRID24722188 details
NDE1_HUMANHXA2_HUMANBioGRID24722188 details
NDE1_HUMANLZTS2_HUMANBioGRID24722188 details
NDE1_HUMANMED4_HUMANBioGRID24722188 details
NDE1_HUMANMKRN3_HUMANBioGRID24722188 details
NDE1_HUMANNDC80_HUMANBioGRID24722188 details
NDE1_HUMANREL_HUMANBioGRID24722188 details
NDE1_HUMANTFP11_HUMANBioGRID24722188 details
NDE1_HUMANTTC1_HUMANBioGRID24722188 details
NDE1_HUMANUBQL1_HUMANBioGRID24722188 details
NDE1_HUMANUSBP1_HUMANBioGRID24722188 details
NDE1_HUMANWAC_HUMANBioGRID24722188 details
NDE1_HUMANZN398_HUMANBioGRID24722188 details
NDE1_HUMANFBX7_HUMANBioGRID27503909 details
NDE1_HUMAN1433Z_HUMANMINT15161933 details
NDE1_HUMANCENPF_HUMANIntAct17600710 details
NDE1_HUMAN1433E_HUMANIntAct25332407 details
NDE1_HUMANTBG1_HUMANBioGRID, HPRD11163258 details
NDE1_HUMANUTRN_HUMANBioGRID22028625 details
NDE1_HUMANMK01_HUMANHPRD12556484 details
NDE1_HUMAN1433G_HUMANHPRD15324660 details