Entity Details

Primary name MED13_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UHV7
EntryNameMED13_HUMAN
FullNameMediator of RNA polymerase II transcription subunit 13
TaxID9606
Evidenceevidence at protein level
Length2174
SequenceStatuscomplete
DateCreated2003-02-22
DateModified2021-06-02

Ontological Relatives

GenesMED13

GO terms

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GOName
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0016020 membrane
GO:0016592 mediator complex
GO:0030374 nuclear receptor coactivator activity
GO:0042809 vitamin D receptor binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046966 thyroid hormone receptor binding
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR009401 Mediator complex subunit Med13, C-terminalDomainDomain
IPR041285 MID domain of medPIWIDomainDomain

Diseases

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Disease IDSourceNameDescription
618009 OMIMIntellectual developmental disorder, autosomal dominant 61 (MRD61)An autosomal dominant form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD61 is characterized by global developmental delay apparent in infancy with mildly impaired intellectual development, expressive speech delay, and behavioral abnormalities, including autism spectrum disorder and attention deficit-hyperactivity disorder. Additional features are highly variable and may include non-specific dysmorphic features, obstipation, ocular anomalies, and poor overall growth. The disease is caused by variants affecting the gene represented in this entry.

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
MED13_HUMANMED23_HUMANBioGRID, HPRD, IntAct, MINT12421765 24981860 25281560 29568061 details
MED13_HUMANMED29_HUMANBioGRID, IntAct15175163 15989967 22939629 24981860 29568061 details
MED13_HUMANENOA_HUMANBioGRID, IntAct23414517 details
MED13_HUMANMED18_HUMANBioGRID, IntAct, MINT15989967 20133760 24981860 26344197 28514442 29568061 details
MED13_HUMANMED4_HUMANBioGRID, MINT12421765 22939629 24981860 25281560 29568061 details
MED13_HUMANESR1_HUMANBioGRID, IntAct11867769 31527615 details
MED13_HUMANMED28_HUMANBioGRID15175163 15989967 20133760 24981860 29568061 details
MED13_HUMANSRBP1_HUMANBioGRID10235267 11834832 16799563 details
MED13_HUMANFBXW7_HUMANBioGRID23322298 25720964 26091241 31285543 details
MED13_HUMANT22D2_HUMANBioGRID27337956 details
MED13_HUMANMED19_HUMANBioGRID, IntAct14576168 15175163 21729782 23563140 24981860 26186194 26344197 28514442 29568061 details
MED13_HUMANMED10_HUMANBioGRID, IntAct10882111 14576168 15175163 15989967 24981860 26344197 29568061 details
MED13_HUMANMED26_HUMANBioGRID, IntAct15175163 21729782 23563140 24981860 details
MED13_HUMANCDK8_HUMANBioGRID, DIP, IntAct10198638 10882111 11867769 19047373 20098423 23322298 23602568 23746844 24981860 26186194 26496610 28514442 29568061 30695077 details
MED13_HUMANMED12_HUMANBioGRID, HPRD, IntAct15175163 20133760 24981860 26344197 26496610 27684187 29568061 details
MED13_HUMANMED7_HUMANBioGRID, IntAct, MINT23563140 24981860 26186194 28514442 29568061 details
MED13_HUMANMED1_HUMANBioGRID, DIP, IntAct15989967 20098423 20133760 23322298 23563140 24981860 26344197 28514442 29568061 details
MED13_HUMANDISC1_HUMANIntAct31413325 details
MED13_HUMANMED30_HUMANBioGRID, MINT15989967 24981860 29568061 details
MED13_HUMANVDR_HUMANBioGRID10198638 10235266 details
MED13_HUMANTRRAP_HUMANBioGRID18418385 details
MED13_HUMANSUPT3_HUMANBioGRID17967894 details
MED13_HUMANZC3HD_HUMANBioGRID20133760 details
MED13_HUMANTRIP4_HUMANBioGRID20133760 details
MED13_HUMANSTN1_HUMANBioGRID20133760 details
MED13_HUMANQKI_HUMANBioGRID20133760 details
MED13_HUMANMED25_HUMANBioGRID14657022 29568061 details
MED13_HUMANMED15_HUMANBioGRID14657022 24981860 29568061 details
MED13_HUMANMD13L_HUMANBioGRID, HPRD15175163 24981860 29568061 details