Entity Details

Primary name MCM8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UJA3
EntryNameMCM8_HUMAN
FullNameDNA helicase MCM8
TaxID9606
Evidenceevidence at protein level
Length840
SequenceStatuscomplete
DateCreated2003-01-17
DateModified2021-06-02

Ontological Relatives

GenesMCM8

GO terms

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GOName
GO:0000724 double-strand break repair via homologous recombination
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007292 female gamete generation
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
GO:0032406 MutLbeta complex binding
GO:0032407 MutSalpha complex binding
GO:0032408 MutSbeta complex binding
GO:0036298 recombinational interstrand cross-link repair
GO:0036388 pre-replicative complex assembly
GO:0042555 MCM complex
GO:0048232 male gamete generation
GO:0050821 protein stabilization
GO:0071168 protein localization to chromatin
GO:0097362 MCM8-MCM9 complex

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001208 MCM domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031327 Mini-chromosome maintenance proteinFamilyFamily
IPR033762 MCM OB domainDomainDomain
IPR041562 MCM, AAA-lid domainDomainDomain

Diseases

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Disease IDSourceNameDescription
612885 OMIMPremature ovarian failure 10 (POF10)An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. The disease is caused by variants affecting the gene represented in this entry.