Entity Details

Primary name BUB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43683
EntryNameBUB1_HUMAN
FullNameMitotic checkpoint serine/threonine-protein kinase BUB1
TaxID9606
Evidenceevidence at protein level
Length1085
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesBUB1

GO terms

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GOName
GO:0000776 kinetochore
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007052 mitotic spindle organization
GO:0007063 regulation of sister chromatid cohesion
GO:0007093 mitotic cell cycle checkpoint signaling
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0008283 cell population proliferation
GO:0016020 membrane
GO:0016032 viral process
GO:0043231 intracellular membrane-bounded organelle
GO:0051301 cell division
GO:0051754 meiotic sister chromatid cohesion, centromeric
GO:0051983 regulation of chromosome segregation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013212 Mad3/Bub1 homology region 1DomainDomain
IPR015661 Mitotic spindle checkpoint protein Bub1/Mad3FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
BUB1_HUMANCRK_HUMANBioGRID, HPRD, IntAct16189514 details
BUB1_HUMANARI2_HUMANBioGRID, HPRD, IntAct16189514 31515488 32296183 details
BUB1_HUMANKNL1_HUMANBioGRID, DIP, IntAct17981135 19141287 20220147 20360068 21199919 22660415 26148513 26186194 26496610 28514442 details
BUB1_HUMANBUB1B_HUMANBioGRID, IntAct20220147 20360068 25852190 26148513 26186194 28514442 31515488 9914370 details
BUB1_HUMANBUB3_HUMANBioGRID, HPRD, IntAct11283619 16760428 20220147 21988832 25416956 26148513 26186194 26496610 28514442 9660858 details
BUB1_HUMANRDH12_HUMANBioGRID, IntAct21988832 details
BUB1_HUMANAPC_HUMANBioGRID, HPRD, IntAct11283619 25241761 details
BUB1_HUMANAKT1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANALDOB_HUMANBioGRID, MINT24412244 details
BUB1_HUMANTRMO_HUMANBioGRID, MINT24412244 details
BUB1_HUMANAN32B_HUMANBioGRID, MINT24412244 details
BUB1_HUMANBAAT_HUMANBioGRID, MINT24412244 details
BUB1_HUMANAMPO_HUMANBioGRID, MINT24412244 details
BUB1_HUMANMSD3_HUMANBioGRID, MINT24412244 details
BUB1_HUMANTSTD2_HUMANBioGRID, MINT24412244 details
BUB1_HUMANCC14B_HUMANBioGRID, MINT24412244 details
BUB1_HUMANCDK8_HUMANBioGRID, MINT24412244 details
BUB1_HUMANCOR2A_HUMANBioGRID, MINT24412244 details
BUB1_HUMANCATL2_HUMANBioGRID, MINT24412244 details
BUB1_HUMANCYLC2_HUMANBioGRID, MINT24412244 details
BUB1_HUMANDVL1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANFANCC_HUMANBioGRID, MINT24412244 details
BUB1_HUMANF16P1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANF16P2_HUMANBioGRID, MINT24412244 details
BUB1_HUMANFRAT2_HUMANBioGRID, MINT24412244 details
BUB1_HUMANGLT12_HUMANBioGRID, MINT24412244 details
BUB1_HUMANHEMGN_HUMANBioGRID, MINT24412244 details
BUB1_HUMANRASH_HUMANBioGRID, MINT24412244 details
BUB1_HUMANDHB3_HUMANBioGRID, MINT24412244 details
BUB1_HUMANIBP3_HUMANBioGRID, MINT24412244 details
BUB1_HUMANLEF1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANCC180_HUMANBioGRID, MINT24412244 details
BUB1_HUMANMAPK3_HUMANMINT24412244 details
BUB1_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANSIAS_HUMANBioGRID, MINT24412244 details
BUB1_HUMANPP2AB_HUMANBioGRID, MINT24412244 details
BUB1_HUMANCANB2_HUMANBioGRID, MINT24412244 details
BUB1_HUMANRASA1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANSC61B_HUMANBioGRID, MINT24412244 details
BUB1_HUMANSFRP2_HUMANBioGRID, MINT24412244 details
BUB1_HUMANSFRP4_HUMANBioGRID, MINT24412244 details
BUB1_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANSHC1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANSTX17_HUMANBioGRID, MINT24412244 details
BUB1_HUMANTBD2A_HUMANBioGRID, MINT24412244 details
BUB1_HUMANTDRD7_HUMANBioGRID, MINT24412244 details
BUB1_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANTMOD1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANTEFF1_HUMANBioGRID, MINT24412244 details
BUB1_HUMANZN189_HUMANBioGRID, MINT24412244 details
BUB1_HUMANXPA_HUMANBioGRID, MINT24412244 details
BUB1_HUMANZN510_HUMANBioGRID, MINT24412244 details
BUB1_HUMANCDC20_HUMANBioGRID, HPRD, IntAct15525512 23443559 25306918 25669885 26186194 26496610 26811472 26912231 28514442 31118282 details
BUB1_HUMANSVIL_HUMANBioGRID, HPRD20309963 details
BUB1_HUMANPLK1_HUMANBioGRID, HPRD16760428 details
BUB1_HUMANCDK1_HUMANBioGRID, HPRD16760428 details
BUB1_HUMANMD2L1_HUMANBioGRID25422469 25669885 details
BUB1_HUMANFBX7_HUMANBioGRID27503909 details
BUB1_HUMANMK03_HUMANBioGRID24412244 details
BUB1_HUMANAP2B1_HUMANHPRD12419313 details
BUB1_HUMANAP3B1_HUMANHPRD12419313 details
BUB1_HUMANAP1B1_HUMANHPRD12419313 details
BUB1_HUMANAP4B1_HUMANHPRD12419313 details
BUB1_HUMANZW10_HUMANUniProt15824131 details
BUB1_HUMANNDEL1_HUMANIntAct17600710 details
BUB1_HUMANMIS12_HUMANBioGRID, IntAct17981135 20360068 21199919 26186194 28514442 details
BUB1_HUMANNSL1_HUMANBioGRID, IntAct20231385 20360068 21199919 details
BUB1_HUMAN4EBP1_HUMANBioGRID, HPRD, IntAct10198256 25241761 details
BUB1_HUMANHSF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
BUB1_HUMANCF161_HUMANBioGRID, IntAct27173435 unassigned1312 details
BUB1_HUMANRAE1L_HUMANBioGRID, HPRD, IntAct11352911 26186194 28514442 details
BUB1_HUMANHDAC1_HUMANBioGRID, HPRD15388328 details
BUB1_HUMANCENPE_HUMANBioGRID9914370 details
BUB1_HUMANTP53B_HUMANBioGRID25963654 details