Entity Details

Primary name SHAN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y566
EntryNameSHAN1_HUMAN
FullNameSH3 and multiple ankyrin repeat domains protein 1
TaxID9606
Evidenceevidence at protein level
Length2161
SequenceStatuscomplete
DateCreated2002-07-26
DateModified2021-06-02

Ontological Relatives

GenesSHANK1

GO terms

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GOName
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007616 long-term memory
GO:0008022 protein C-terminus binding
GO:0008306 associative learning
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0017124 SH3 domain binding
GO:0030160 synaptic receptor adaptor activity
GO:0030425 dendrite
GO:0030534 adult behavior
GO:0031877 somatostatin receptor binding
GO:0032232 negative regulation of actin filament bundle assembly
GO:0035176 social behavior
GO:0035255 ionotropic glutamate receptor binding
GO:0035418 protein localization to synapse
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0044877 protein-containing complex binding
GO:0045211 postsynaptic membrane
GO:0048854 brain morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0050894 determination of affect
GO:0051124 synaptic assembly at neuromuscular junction
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060074 synapse maturation
GO:0060076 excitatory synapse
GO:0060291 long-term synaptic potentiation
GO:0060997 dendritic spine morphogenesis
GO:0060999 positive regulation of dendritic spine development
GO:0065003 protein-containing complex assembly
GO:0071532 ankyrin repeat binding
GO:0071625 vocalization behavior
GO:0097107 postsynaptic density assembly
GO:0097110 scaffold protein binding
GO:2000311 regulation of AMPA receptor activity
GO:2000463 positive regulation of excitatory postsynaptic potential

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR001660 Sterile alpha motif domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR041489 PDZ domain 6DomainDomain

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
SHAN1_HUMANAGRL2_HUMANBioGRID, HPRD, MINT10964907 details
SHAN1_HUMANAGRB2_HUMANBioGRID, MINT10964907 details
SHAN1_HUMANSTAT1_HUMANBioGRID, IntAct20936779 details
SHAN1_HUMANBI2L1_HUMANDIP21098279 details
SHAN1_HUMANCRCM_HUMANIntAct30126976 details
SHAN1_HUMANKS6A2_HUMANHPRD, IntAct16217014 30126976 details
SHAN1_HUMANTB10C_HUMANIntAct30126976 details
SHAN1_HUMANWWTR1_HUMANIntAct30126976 details
SHAN1_HUMANS26A6_HUMANIntAct30126976 details
SHAN1_HUMANMELT_HUMANIntAct30126976 details
SHAN1_HUMANTM219_HUMANIntAct30126976 details
SHAN1_HUMANYAP1_HUMANIntAct30126976 details
SHAN1_HUMANCAC1D_HUMANUniProt30058071 details
SHAN1_HUMANDYN2_HUMANBioGRID, HPRD11583995 details
SHAN1_HUMANARHG7_HUMANBioGRID, HPRD12626503 details
SHAN1_HUMANSHAN1_HUMANBioGRID, HPRD12954649 23897824 details
SHAN1_HUMANBAIP2_HUMANBioGRID, HPRD12504591 15255944 details
SHAN1_HUMANSSR2_HUMANBioGRID, HPRD10551867 11087996 details
SHAN1_HUMANSHRPN_HUMANBioGRID, HPRD11178875 12753155 details
SHAN1_HUMANSPTN1_HUMANBioGRID, HPRD11509555 details
SHAN1_HUMANUBP8_HUMANBioGRID29735556 details
SHAN1_HUMANACE2_HUMANBioGRID33436498 details
SHAN1_HUMANKS6A3_HUMANHPRD16217014 details
SHAN1_HUMANHOME1_HUMANHPRD10433269 details
SHAN1_HUMANAGRL1_HUMANHPRD10958799 10964907 details
SHAN1_HUMANDLGP1_HUMANBioGRID, HPRD, MINT12954649 20573181 details
SHAN1_HUMANH4_HUMANBioGRID, IntAct30021884 details
SHAN1_HUMANFXR1_HUMANMINT21653829 details
SHAN1_HUMANSHAN3_HUMANMINT21653829 details
SHAN1_HUMANTSC1_HUMANMINT21653829 details
SHAN1_HUMANDLG4_HUMANBioGRID, HPRD10433268 15255944 details
SHAN1_HUMANTANC1_HUMANHPRD15673434 details
SHAN1_HUMANABCA1_HUMANHPRD16192279 details