Entity Details

Primary name WDR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75083
EntryNameWDR1_HUMAN
FullNameWD repeat-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length606
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesWDR1

GO terms

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GOName
GO:0002102 podosome
GO:0002446 neutrophil mediated immunity
GO:0002576 platelet degranulation
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0007605 sensory perception of sound
GO:0008360 regulation of cell shape
GO:0030042 actin filament depolymerization
GO:0030043 actin filament fragmentation
GO:0030054 cell junction
GO:0030220 platelet formation
GO:0030834 regulation of actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
GO:0030864 cortical actin cytoskeleton
GO:0030865 cortical cytoskeleton organization
GO:0040011 locomotion
GO:0042247 establishment of planar polarity of follicular epithelium
GO:0042995 cell projection
GO:0043297 apical junction assembly
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0045214 sarcomere organization
GO:0048713 regulation of oligodendrocyte differentiation
GO:0051015 actin filament binding
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0070062 extracellular exosome
GO:1990266 neutrophil migration

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR011045 Nitrous oxide reductase, N-terminalFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
150550 OMIMPeriodic fever, immunodeficiency, and thrombocytopenia syndrome (PFITS)An immunologic disorder with variable manifestations including early-onset recurrent respiratory infections, stomatitis, cutaneous infections, and neutropenia. The disease is caused by variants affecting the gene represented in this entry.