Entity Details

Primary name TRPA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75762
EntryNameTRPA1_HUMAN
FullNameTransient receptor potential cation channel subfamily A member 1
TaxID9606
Evidenceevidence at protein level
Length1119
SequenceStatuscomplete
DateCreated2004-12-21
DateModified2021-06-02

Ontological Relatives

GenesTRPA1

GO terms

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GOName
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0007166 cell surface receptor signaling pathway
GO:0009409 response to cold
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0015267 channel activity
GO:0015278 calcium-release channel activity
GO:0019233 sensory perception of pain
GO:0032421 stereocilium bundle
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0048265 response to pain
GO:0050955 thermoception
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0050968 detection of chemical stimulus involved in sensory perception of pain
GO:0051289 protein homotetramerization
GO:0070588 calcium ion transmembrane transport
GO:0097604 temperature-gated cation channel activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR002110 Ankyrin repeatRepeatRepeat
IPR005821 Ion transport domainDomainDomain
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615040 OMIMEpisodic pain syndrome, familial, 1 (FEPS1)An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not manifest altered pain sensitivity outside the episodes. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00825 LevomentholDrugbanksmall molecule
DB01744 CamphorDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11345 (S)-camphorDrugbanksmall molecule
DB11755 TetrahydrocannabivarinDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14050 CannabidivarinDrugbanksmall molecule

Interactions

3 interactions