Entity Details

Primary name AL1A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO94788
EntryNameAL1A2_HUMAN
FullNameRetinal dehydrogenase 2
TaxID9606
Evidenceevidence at protein level
Length518
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesALDH1A2

GO terms

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GOName
GO:0001568 blood vessel development
GO:0001758 retinal dehydrogenase activity
GO:0001822 kidney development
GO:0001889 liver development
GO:0001936 regulation of endothelial cell proliferation
GO:0002138 retinoic acid biosynthetic process
GO:0003007 heart morphogenesis
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006776 vitamin A metabolic process
GO:0007494 midgut development
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009855 determination of bilateral symmetry
GO:0009954 proximal/distal pattern formation
GO:0010628 positive regulation of gene expression
GO:0014032 neural crest cell development
GO:0016331 morphogenesis of embryonic epithelium
GO:0016918 retinal binding
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0030182 neuron differentiation
GO:0030324 lung development
GO:0030902 hindbrain development
GO:0031016 pancreas development
GO:0031076 embryonic camera-type eye development
GO:0032355 response to estradiol
GO:0033189 response to vitamin A
GO:0034097 response to cytokine
GO:0035115 embryonic forelimb morphogenesis
GO:0035799 ureter maturation
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0048471 perinuclear region of cytoplasm
GO:0048566 embryonic digestive tract development
GO:0048738 cardiac muscle tissue development
GO:0051289 protein homotetramerization
GO:0060324 face development
GO:0071300 cellular response to retinoic acid
GO:0090242 retinoic acid receptor signaling pathway involved in somitogenesis

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR015590 Aldehyde dehydrogenase domainDomainDomain
IPR016160 Aldehyde dehydrogenase, cysteine active siteSiteConserved site
IPR016161 Aldehyde/histidinol dehydrogenaseFamilyHomologous superfamily
IPR016162 Aldehyde dehydrogenase, N-terminalFamilyHomologous superfamily
IPR016163 Aldehyde dehydrogenase, C-terminalFamilyHomologous superfamily
IPR029510 Aldehyde dehydrogenase, glutamic acid active siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00162 Vitamin ADrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule

Interactions

4 interactions