Entity Details

Primary name GRP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95267
EntryNameGRP1_HUMAN
FullNameRAS guanyl-releasing protein 1
TaxID9606
Evidenceevidence at protein level
Length797
SequenceStatuscomplete
DateCreated2008-02-05
DateModified2021-06-02

Ontological Relatives

GenesRASGRP1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000165 MAPK cascade
GO:0001934 positive regulation of protein phosphorylation
GO:0002250 adaptive immune response
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0016020 membrane
GO:0019992 diacylglycerol binding
GO:0030101 natural killer cell activation
GO:0030154 cell differentiation
GO:0031210 phosphatidylcholine binding
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046330 positive regulation of JNK cascade
GO:0046579 positive regulation of Ras protein signal transduction
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090630 activation of GTPase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GRP1_HUMANFMR1_HUMANIntAct31413325 details
GRP1_HUMANDGKZ_HUMANBioGRID, HPRD11257115 details
GRP1_HUMANRASH_HUMANHPRD9582122 details