Entity Details

Primary name A2MG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01023
EntryNameA2MG_HUMAN
FullNameAlpha-2-macroglobulin
TaxID9606
Evidenceevidence at protein level
Length1474
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesA2M

GO terms

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GOName
GO:0001869 negative regulation of complement activation, lectin pathway
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0019838 growth factor binding
GO:0019899 enzyme binding
GO:0019959 interleukin-8 binding
GO:0019966 interleukin-1 binding
GO:0022617 extracellular matrix disassembly
GO:0031093 platelet alpha granule lumen
GO:0043120 tumor necrosis factor binding
GO:0048306 calcium-dependent protein binding
GO:0048863 stem cell differentiation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:2000267 negative regulation of blood coagulation, intrinsic pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001599 Alpha-2-macroglobulinDomainDomain
IPR002890 Macroglobulin domainDomainDomain
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroidFamilyHomologous superfamily
IPR009048 Alpha-macroglobulin, receptor-bindingDomainDomain
IPR010916 TonB box, conserved siteSiteConserved site
IPR011625 Alpha-2-macroglobulin, bait region domainDomainDomain
IPR011626 Alpha-macroglobulin-like, TED domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR019742 Alpha-2-macroglobulin, conserved siteSiteConserved site
IPR036595 Alpha-macroglobulin, receptor-binding domain superfamilyFamilyHomologous superfamily
IPR040839 Macroglobulin domain MG4DomainDomain
IPR041555 Macroglobulin domain MG3DomainDomain
IPR041813 Alpha-2-macroglobulin, TED domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00102 BecaplerminDrugbankbiotech
DB00515 CisplatinDrugbanksmall molecule
DB00626 BacitracinDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB06796 MangafodipirSwissprotsmall molecule
DB08888 OcriplasminDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB12965 SilverDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

152 interactions

InteractorPartnerSourcesPublicationsLink
A2MG_HUMANSMAP_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
A2MG_HUMANACTB_HUMANBioGRID, MINT17174955 21163940 details
A2MG_HUMANBIP_HUMANBioGRID, HPRD, MINT12194978 17174955 details
A2MG_HUMANGEM_HUMANBioGRID, IntAct18624398 details
A2MG_HUMANGRB2_HUMANBioGRID, IntAct18624398 details
A2MG_HUMANCDC42_HUMANBioGRID, IntAct18624398 details
A2MG_HUMANUMPS_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANNCDN_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANLST8_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANNOS3_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANA4_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANAPOE_HUMANBioGRID, HPRD, IntAct21163940 9831625 details
A2MG_HUMANEXOS1_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANELAV3_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANECSIT_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANPRDX2_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANRHEB_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANOGA_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANIFIT3_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANSYFA_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANPRAM_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANRNF32_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANTPPC5_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANIFIT5_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANPAXI1_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANRD23A_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANCP2CI_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANCP2C8_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANLONM_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANGCDH_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANMAST1_HUMANBioGRID, IntAct21163940 details
A2MG_HUMANTGM2_HUMANBioGRID, IntAct21988832 details
A2MG_HUMANANXA7_HUMANBioGRID, MINT21900206 details
A2MG_HUMANCDKA2_HUMANBioGRID, MINT21900206 details
A2MG_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
A2MG_HUMANH2AX_HUMANBioGRID, MINT21900206 details
A2MG_HUMANHMOX2_HUMANBioGRID, MINT21900206 details
A2MG_HUMANCPSF5_HUMANBioGRID, MINT21900206 details
A2MG_HUMANRAP1B_HUMANBioGRID, MINT21900206 details
A2MG_HUMANRPP14_HUMANBioGRID, MINT21900206 details
A2MG_HUMANSEPT8_HUMANBioGRID, MINT21900206 details
A2MG_HUMANSMN_HUMANBioGRID, IntAct, MINT21900206 32814053 details
A2MG_HUMANTGIF1_HUMANBioGRID, MINT21900206 details
A2MG_HUMANKITH_HUMANBioGRID, MINT21900206 details
A2MG_HUMANTNR14_HUMANBioGRID, MINT21900206 details
A2MG_HUMANT22D1_HUMANBioGRID, MINT21900206 details
A2MG_HUMANTTHY_HUMANBioGRID, MINT21900206 details
A2MG_HUMANUFD1_HUMANBioGRID, MINT21900206 details
A2MG_HUMANIL10_HUMANBioGRID, HPRD, IntAct10714547 25241761 details
A2MG_HUMANMMP2_HUMANBioGRID, HPRD, IntAct25241761 9344465 details
A2MG_HUMANATS12_HUMANbhf-ucl18485748 details
A2MG_HUMANATS7_HUMANbhf-ucl18485748 details
A2MG_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
A2MG_HUMANCTNB1_HUMANIntAct32814053 details
A2MG_HUMANCSF2_HUMANIntAct32814053 details
A2MG_HUMANPRDM1_HUMANIntAct32814053 details
A2MG_HUMANAP2B1_HUMANIntAct32814053 details
A2MG_HUMANH2AZ_HUMANIntAct32814053 details
A2MG_HUMANTHIO_HUMANIntAct32814053 details
A2MG_HUMANTEAD1_HUMANIntAct32814053 details
A2MG_HUMANP85A_HUMANIntAct32814053 details
A2MG_HUMANBRK1_HUMANIntAct32814053 details
A2MG_HUMANRN112_HUMANIntAct32814053 details
A2MG_HUMANMNDA_HUMANIntAct32814053 details
A2MG_HUMANLYN_HUMANIntAct32814053 details
A2MG_HUMANHXC4_HUMANIntAct32814053 details
A2MG_HUMANFZD4_HUMANIntAct32814053 details
A2MG_HUMANH31_HUMANIntAct32814053 details
A2MG_HUMANCSN3_HUMANIntAct32814053 details
A2MG_HUMANPIAS1_HUMANIntAct32814053 details
A2MG_HUMANSTX11_HUMANIntAct32814053 details
A2MG_HUMANIQEC1_HUMANIntAct32814053 details
A2MG_HUMANCHIP_HUMANIntAct32814053 details
A2MG_HUMANCLC2B_HUMANIntAct32814053 details
A2MG_HUMANKAT5_HUMANIntAct32814053 details
A2MG_HUMANUT14A_HUMANIntAct32814053 details
A2MG_HUMANDDX20_HUMANIntAct32814053 details
A2MG_HUMANTWST2_HUMANIntAct32814053 details
A2MG_HUMANTDIF1_HUMANIntAct32814053 details
A2MG_HUMANTRI69_HUMANIntAct32814053 details
A2MG_HUMANRN183_HUMANIntAct32814053 details
A2MG_HUMANATIF1_HUMANIntAct32814053 details
A2MG_HUMANMOFA1_HUMANIntAct32814053 details
A2MG_HUMANHUMMR_HUMANIntAct32814053 details
A2MG_HUMANLNX1_HUMANIntAct32814053 details
A2MG_HUMANVP33A_HUMANIntAct32814053 details
A2MG_HUMANAB17C_HUMANIntAct32814053 details
A2MG_HUMANDAZ3_HUMANIntAct32814053 details
A2MG_HUMANOTU7B_HUMANIntAct32814053 details
A2MG_HUMANOTUB1_HUMANIntAct32814053 details
A2MG_HUMANVPS29_HUMANIntAct32814053 details
A2MG_HUMANLHX6_HUMANIntAct32814053 details
A2MG_HUMANERAL1_HUMANIntAct32814053 details
A2MG_HUMANRAB38_HUMANIntAct32814053 details
A2MG_HUMANCYFP1_HUMANIntAct32814053 details
A2MG_HUMANPARK7_HUMANIntAct32814053 details
A2MG_HUMANFOXR1_HUMANIntAct32814053 details
A2MG_HUMANZN366_HUMANIntAct32814053 details
A2MG_HUMANKRA81_HUMANIntAct32814053 details
A2MG_HUMANSTX19_HUMANIntAct32814053 details
A2MG_HUMANFOXA2_HUMANIntAct32814053 details
A2MG_HUMANKR107_HUMANIntAct32814053 details
A2MG_HUMANSPT12_HUMANIntAct32814053 details
A2MG_HUMANS100B_HUMANIntAct32814053 details
A2MG_HUMANKSYK_HUMANIntAct32814053 details
A2MG_HUMANKLK13_HUMANBioGRID14687906 details
A2MG_HUMANCBPB2_HUMANBioGRID8662763 details
A2MG_HUMANPAEP_HUMANBioGRID, HPRD11023837 details
A2MG_HUMANLEP_HUMANBioGRID, HPRD9724081 details
A2MG_HUMANB2MG_HUMANBioGRID, HPRD10731476 details
A2MG_HUMANLCAT_HUMANBioGRID, HPRD11435418 details
A2MG_HUMANNGF_HUMANBioGRID, HPRD10681572 details
A2MG_HUMANIL4_HUMANBioGRID10714547 details
A2MG_HUMANSHBG_HUMANBioGRID, HPRD15862967 details
A2MG_HUMANMYOC_HUMANBioGRID, HPRD16289162 details
A2MG_HUMANA2MG_HUMANBioGRID21163940 details
A2MG_HUMANAP1M2_HUMANBioGRID21163940 details
A2MG_HUMANSWAP1_HUMANBioGRID21163940 details
A2MG_HUMANCDC37_HUMANBioGRID21163940 details
A2MG_HUMANDNJB1_HUMANBioGRID21163940 details
A2MG_HUMANEVI5L_HUMANBioGRID21163940 details
A2MG_HUMANFXL12_HUMANBioGRID21163940 details
A2MG_HUMANFBXW4_HUMANBioGRID21163940 details
A2MG_HUMANRAB3A_HUMANBioGRID21163940 details
A2MG_HUMANRETN_HUMANBioGRID21163940 details
A2MG_HUMANSTALP_HUMANBioGRID21163940 details
A2MG_HUMANAT1A1_HUMANBioGRID21163940 details
A2MG_HUMANEGLN2_HUMANBioGRID21163940 details
A2MG_HUMANENOG_HUMANBioGRID21163940 details
A2MG_HUMANFIS1_HUMANBioGRID21163940 details
A2MG_HUMANIGSF8_HUMANBioGRID21163940 details
A2MG_HUMANTBA1B_HUMANBioGRID21163940 details
A2MG_HUMANTYRO3_HUMANBioGRID21163940 details
A2MG_HUMANKLK1_HUMANBioGRID3643793 details
A2MG_HUMANSC6A4_HUMANBioGRID7686585 details
A2MG_HUMANHS90A_HUMANBioGRID31273033 details
A2MG_HUMANMCAF1_HUMANHPRD15231748 details
A2MG_HUMANSACA3_HUMANIntAct2467766 details
A2MG_HUMANIL1B_HUMANBioGRID, HPRD, IntAct2466831 25241761 9714181 details
A2MG_HUMANKLK3_HUMANBioGRID, HPRD, IntAct1702714 25241761 8583572 details
A2MG_HUMANATS1_HUMANBioGRID, HPRD10373500 details
A2MG_HUMANLRP1_HUMANBioGRID, HPRD10652313 12194978 details
A2MG_HUMANAMBP_HUMANBioGRID, HPRD1697852 7519849 7533162 details
A2MG_HUMANANXA6_HUMANHPRD15226301 details
A2MG_HUMANLYSC_HUMANHPRD2467766 details
A2MG_HUMANCATB_HUMANHPRD2476070 details
A2MG_HUMANCATE_HUMANHPRD12631277 details
A2MG_HUMANCELA1_HUMANHPRD6153632 6191979 80233 details
A2MG_HUMANKLK2_HUMANHPRD9428387 details
A2MG_HUMANPDGFA_HUMANHPRD10681572 details
A2MG_HUMANPDGFB_HUMANHPRD10681572 details
A2MG_HUMANBGH3_HUMANHPRD10681572 details