Entity Details

Primary name TGFB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01137
EntryNameTGFB1_HUMAN
FullNameTransforming growth factor beta-1 proprotein
TaxID9606
Evidenceevidence at protein level
Length390
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTGFB1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001570 vasculogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001843 neural tube closure
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002062 chondrocyte differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0002576 platelet degranulation
GO:0003179 heart valve morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003823 antigen binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0006754 ATP biosynthetic process
GO:0006796 phosphate-containing compound metabolic process
GO:0006954 inflammatory response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007183 SMAD protein complex assembly
GO:0007435 salivary gland morphogenesis
GO:0007507 heart development
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009611 response to wounding
GO:0009986 cell surface
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010742 macrophage derived foam cell differentiation
GO:0010763 positive regulation of fibroblast migration
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 negative regulation of macrophage cytokine production
GO:0014008 positive regulation of microglia differentiation
GO:0016202 regulation of striated muscle tissue development
GO:0016477 cell migration
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0021915 neural tube development
GO:0022408 negative regulation of cell-cell adhesion
GO:0030214 hyaluronan catabolic process
GO:0030308 negative regulation of cell growth
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0032740 positive regulation of interleukin-17 production
GO:0032801 receptor catabolic process
GO:0032930 positive regulation of superoxide anion generation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034713 type I transforming growth factor beta receptor binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0035307 positive regulation of protein dephosphorylation
GO:0042127 regulation of cell population proliferation
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042802 identical protein binding
GO:0043117 positive regulation of vascular permeability
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043932 ossification involved in bone remodeling
GO:0045216 cell-cell junction organization
GO:0045596 negative regulation of cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045918 negative regulation of cytolysis
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048535 lymph node development
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0050921 positive regulation of chemotaxis
GO:0051098 regulation of binding
GO:0051101 regulation of DNA binding
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060312 regulation of blood vessel remodeling
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060390 regulation of SMAD protein signal transduction
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060395 SMAD protein signal transduction
GO:0060965 negative regulation of gene silencing by miRNA
GO:0062023 collagen-containing extracellular matrix
GO:0070168 negative regulation of biomineral tissue development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070723 response to cholesterol
GO:0071407 cellular response to organic cyclic compound
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072562 blood microparticle
GO:0085029 extracellular matrix assembly
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:1900182 positive regulation of protein localization to nucleus
GO:1901203 positive regulation of extracellular matrix assembly
GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903077 negative regulation of protein localization to plasma membrane
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905313 transforming growth factor beta receptor signaling pathway involved in heart development
GO:1990402 embryonic liver development
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000727 positive regulation of cardiac muscle cell differentiation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR003939 Transforming growth factor beta-1 proproteinFamilyFamily
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR016319 Transforming growth factor-betaFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618213 OMIMInflammatory bowel disease, immunodeficiency, and encephalopathy (IBDIMDE)An autosomal recessive disorder characterized by severe infantile inflammatory bowel disease manifesting as bloody diarrhea and failure to thrive, global developmental delay, epilepsy, brain atrophy and encephalopathy. Affected individuals suffer from recurrent infections associated with impaired T-cell response to stimulation and decreased T-cell subsets, including regulatory and helper T cells. The disease is caused by variants affecting the gene represented in this entry.
131300 OMIMCamurati-Engelmann disease (CAEND)An autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00070 Hyaluronidase (ovine)Drugbankbiotech
DB01162 TerazosinDrugbanksmall molecule
DB06205 Hyaluronidase (human recombinant)Drugbankbiotech
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB14740 HyaluronidaseDrugbankbiotech

Interactions

108 interactions

InteractorPartnerSourcesPublicationsLink
TGFB1_HUMANFSTL1_HUMANMINT20860622 details
TGFB1_HUMANTGFR2_HUMANBioGRID, HPRD, I2D, MINT11157754 20856203 20860622 21054789 21441952 7935686 8242742 8389764 details
TGFB1_HUMANDIP2A_HUMANMINT20860622 details
TGFB1_HUMANWFKN1_HUMANMINT21054789 details
TGFB1_HUMANWFKN2_HUMANMINT21054789 details
TGFB1_HUMANLAMB1_HUMANBioGRID, IntAct20936779 27684187 details
TGFB1_HUMANEGLN_HUMANBioGRID, HPRD, I2D12015308 1326540 20856203 details
TGFB1_HUMANTGBR3_HUMANBioGRID, HPRD, I2D20856203 7935686 8106553 details
TGFB1_HUMANTGFR1_HUMANBioGRID, HPRD, I2D10716993 15597342 20856203 8235612 details
TGFB1_HUMANTSP1_HUMANBioGRID, HPRD, UniProt1550960 15864306 details
TGFB1_HUMANMMP9_HUMANBioGRID, IntAct10652271 25241761 details
TGFB1_HUMANMMP2_HUMANBioGRID, HPRD, IntAct10652271 25241761 details
TGFB1_HUMANAPC_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANAURKA_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANAXIN2_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANBCL10_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANARF_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANRHG07_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANEGFR_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANERBB2_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANCRCM_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANPGFRL_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANTLR2_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANAGR3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANANGL4_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANBLID_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANCCL5_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANCYTM_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANGREB1_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANHXC6_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANKLK5_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANKLK7_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANKLK9_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANMTA3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANPDLI2_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANHOP2_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANSG3A1_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANSNAI1_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANST14_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANTSP50_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANNSD3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANCO5A1_HUMANmatrixdb20979576 details
TGFB1_HUMANMEOX2_HUMANBioGRID, IntAct25416956 details
TGFB1_HUMANLTBP1_HUMANBioGRID, DIP, HPIDb10930463 12429738 21677751 details
TGFB1_HUMANLCE3B_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE2C_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANPO4F2_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE1A_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANPDIA1_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLPXN_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANKR108_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANATL4_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE1D_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE2B_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANKR411_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANCTSR1_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE3A_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE1C_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE3D_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANPSG1_HUMANIntAct25548275 details
TGFB1_HUMANPSG9_HUMANIntAct27389696 details
TGFB1_HUMANTGFB1_HUMANDIP, HPRD10930463 21677751 7935686 8617200 details
TGFB1_HUMANFNTA_HUMANBioGRID, HPRD8599089 details
TGFB1_HUMANVASN_HUMANBioGRID, HPRD15247411 details
TGFB1_HUMANCO2A1_HUMANBioGRID, HPRD10085302 details
TGFB1_HUMANPGS2_HUMANBioGRID, HPRD7638106 7798269 8093006 9675033 details
TGFB1_HUMANPGS1_HUMANBioGRID, HPRD10383378 8093006 details
TGFB1_HUMANFMOD_HUMANBioGRID, HPRD8093006 details
TGFB1_HUMANVTNC_HUMANBioGRID, HPRD11796824 details
TGFB1_HUMAN1433E_HUMANBioGRID, HPRD11172812 details
TGFB1_HUMANFKB1A_HUMANBioGRID11960000 23734213 details
TGFB1_HUMANCCD33_HUMANBioGRID25416956 details
TGFB1_HUMANLTOR5_HUMANBioGRID23241634 details
TGFB1_HUMANRPGF3_HUMANBioGRID32296183 details
TGFB1_HUMANFCHO1_HUMANBioGRID32296183 details
TGFB1_HUMANKRA13_HUMANBioGRID32296183 details
TGFB1_HUMANCDN2A_HUMANBioGRID24412244 details
TGFB1_HUMANA4_HUMANBioGRID, HPRD, IntAct12867422 2119582 25241761 27684187 details
TGFB1_HUMANCILP1_HUMANUniProt15864306 details
TGFB1_HUMANLRC32_HUMANBioGRID, DIP, IntAct19651619 28514442 details
TGFB1_HUMANITAV_HUMANDIP, HPRD11970960 21677751 details
TGFB1_HUMANFCN1_HUMANBioGRID, HPRD7686157 details
TGFB1_HUMANACVL1_HUMANBioGRID, HPRD10716993 8242742 details
TGFB1_HUMANEPS15_HUMANBioGRID19109251 details
TGFB1_HUMANTGFB2_HUMANBioGRID, HPRD11157754 27684187 details
TGFB1_HUMANP85A_HUMANBioGRID15657037 details
TGFB1_HUMANSPRC_HUMANHPRD15034927 details
TGFB1_HUMANCCL3_HUMANHPRD8568261 details
TGFB1_HUMANLTBP3_HUMANHPRD12062452 details
TGFB1_HUMANEIF3I_HUMANHPRD9813058 details
TGFB1_HUMANITB8_HUMANHPRD11970960 details
TGFB1_HUMANLTBP4_HUMANHPRD9660815 details
TGFB1_HUMANBMP2_HUMANHPRD11456401 details
TGFB1_HUMANBMP3_HUMANHPRD9434787 details
TGFB1_HUMANDERM_HUMANHPRD9895299 details
TGFB1_HUMANCCN2_HUMANHPRD10457363 details
TGFB1_HUMANSDC2_HUMANHPRD14976204 details
TGFB1_HUMANITB6_HUMANHPRD10025398 details