Entity Details

Primary name ROS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08922
EntryNameROS1_HUMAN
FullNameProto-oncogene tyrosine-protein kinase ROS
TaxID9606
Evidenceevidence at protein level
Length2347
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesROS1

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0002066 columnar/cuboidal epithelial cell development
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0009986 cell surface
GO:0010467 gene expression
GO:0010629 negative regulation of gene expression
GO:0010966 regulation of phosphate transport
GO:0016020 membrane
GO:0019903 protein phosphatase binding
GO:0030154 cell differentiation
GO:0032006 regulation of TOR signaling
GO:0033674 positive regulation of kinase activity
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0043235 receptor complex
GO:0048471 perinuclear region of cytoplasm
GO:0070372 regulation of ERK1 and ERK2 cascade

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11986 EntrectinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule