Entity Details

Primary name EPHA3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29320
EntryNameEPHA3_HUMAN
FullNameEphrin type-A receptor 3
TaxID9606
Evidenceevidence at protein level
Length983
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesEPHA3

GO terms

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GOName
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010976 positive regulation of neuron projection development
GO:0015629 actin cytoskeleton
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0031965 nuclear membrane
GO:0032956 regulation of actin cytoskeleton organization
GO:0033674 positive regulation of kinase activity
GO:0043005 neuron projection
GO:0043087 regulation of GTPase activity
GO:0043235 receptor complex
GO:0045806 negative regulation of endocytosis
GO:0048013 ephrin receptor signaling pathway
GO:0051893 regulation of focal adhesion assembly
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071300 cellular response to retinoic acid
GO:0097155 fasciculation of sensory neuron axon
GO:0097156 fasciculation of motor neuron axon
GO:1903078 positive regulation of protein localization to plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-likeDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034266 Ephrin type-A receptor 3, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
114500 OMIMColorectal cancer (CRC)A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. The gene represented in this entry may be involved in disease pathogenesis.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
EPHA3_HUMANCDN2A_HUMANBioGRID, IntAct17955473 details
EPHA3_HUMANRUFY1_HUMANHPRD, MINT11877430 details
EPHA3_HUMANRBM18_HUMANBioGRID, IntAct21988832 details
EPHA3_HUMANEPHA7_HUMANBioGRID, IntAct22036564 28514442 details
EPHA3_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
EPHA3_HUMANEFNA5_HUMANBioGRID, DIP, HPRD19823572 9195962 9245480 9751130 details
EPHA3_HUMANCTDS2_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANDUS18_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANDUS21_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANSTYX_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANTPTE_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANILKAP_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANMTMRB_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANP53_HUMANBioGRID, HPRD15355990 details
EPHA3_HUMANEFNB2_HUMANBioGRID, HPRD8559144 9195962 details
EPHA3_HUMANEFNA1_HUMANBioGRID, HPRD8070404 9195962 details
EPHA3_HUMANEFNB1_HUMANBioGRID9195962 details
EPHA3_HUMANEFNA3_HUMANBioGRID9195962 details
EPHA3_HUMANEFNA4_HUMANBioGRID9195962 details
EPHA3_HUMANSRC_HUMANBioGRID9632142 details
EPHA3_HUMANFYN_HUMANBioGRID9632142 details
EPHA3_HUMANABL1_HUMANBioGRID11494128 details
EPHA3_HUMANARF_HUMANBioGRID17955473 details
EPHA3_HUMANFBX7_HUMANBioGRID27503909 details
EPHA3_HUMANERBB2_HUMANBioGRID30898150 details
EPHA3_HUMANRUFY2_HUMANHPRD11877430 details
EPHA3_HUMANCALM2_HUMANDIP19823572 details
EPHA3_HUMANADA10_HUMANDIP, HPRD16239146 19823572 details
EPHA3_HUMANCRK_HUMANBioGRID, HPRD11870224 details
EPHA3_HUMANHS90A_HUMANBioGRID31577226 details
EPHA3_HUMANCLH1_HUMANBioGRID31577226 details
EPHA3_HUMANMYH9_HUMANBioGRID31577226 details
EPHA3_HUMANNCAM1_HUMANBioGRID29670169 details
EPHA3_HUMANEPHA3_HUMANHPRD11870224 details
EPHA3_HUMANEFNA2_HUMANHPRD9751130 details
EPHA3_HUMANPIM1_HUMANHPRD16186805 details
EPHA3_HUMANSTAT3_HUMANHPRD16186805 details