Entity Details

Primary name TPOR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40238
EntryNameTPOR_HUMAN
FullNameThrombopoietin receptor
TaxID9606
Evidenceevidence at protein level
Length635
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesMPL

GO terms

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GOName
GO:0001780 neutrophil homeostasis
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0035702 monocyte homeostasis
GO:0038164 thrombopoietin receptor activity
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0050671 positive regulation of lymphocyte proliferation
GO:0070527 platelet aggregation
GO:0071456 cellular response to hypoxia
GO:1905221 positive regulation of platelet formation
GO:1990959 eosinophil homeostasis
GO:1990960 basophil homeostasis

Subcellular Location

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Subcellular Location
Cell membrane
Cell surface
Golgi apparatus

Domains

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DomainNameCategoryType
IPR003528 Long hematopoietin receptor, single chain, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015152 Growth hormone/erythropoietin receptor, ligand bindingDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
604498 OMIMCongenital amegakaryocytic thrombocytopenia (CAMT)Disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. The disease is caused by variants affecting the gene represented in this entry.
601977 OMIMThrombocythemia 2 (THCYT2)A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. The disease is caused by variants affecting the gene represented in this entry.
254450 OMIMMyelofibrosis (MYELOF)A disorder characterized by replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder. Clinical manifestations may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB05332 RomiplostimDrugbankbiotech
DB05930 SB-559448Drugbanksmall molecule
DB06210 EltrombopagDrugbanksmall molecule
DB06534 ThrombopoietinDrugbankbiotech
DB11995 AvatrombopagDrugbanksmall molecule
DB13125 LusutrombopagDrugbanksmall molecule