Entity Details

Primary name S61A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61619
EntryNameS61A1_HUMAN
FullNameProtein transport protein Sec61 subunit alpha isoform 1
TaxID9606
Evidenceevidence at protein level
Length476
SequenceStatuscomplete
DateCreated2004-06-07
DateModified2021-06-02

Ontological Relatives

GenesSEC61A1

GO terms

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GOName
GO:0005048 signal sequence binding
GO:0005262 calcium channel activity
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane
GO:0007029 endoplasmic reticulum organization
GO:0008320 protein transmembrane transporter activity
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031204 posttranslational protein targeting to membrane, translocation
GO:0039019 pronephric nephron development
GO:0043022 ribosome binding
GO:0045047 protein targeting to ER

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR002208 SecY/SEC61-alpha familyFamilyFamily
IPR019561 Translocon Sec61/SecY, plug domainDomainDomain
IPR023201 SecY domain superfamilyFamilyHomologous superfamily
IPR030659 SecY conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
617056 OMIMFamilial juvenile hyperuricemic nephropathy 4 (HNFJ4)An autosomal dominant renal disorder characterized by progressive chronic kidney disease, anemia, elevated serum creatinine levels, and hyperuricemia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
S61A1_HUMANMLH1_HUMANBioGRID, IntAct20706999 details
S61A1_HUMANBIP_HUMANBioGRID, MINT22796945 26085089 details
S61A1_HUMANBAG6_HUMANBioGRID20676083 details
S61A1_HUMANGET3_HUMANBioGRID20676083 details
S61A1_HUMANCALM1_HUMANBioGRID21102557 details
S61A1_HUMANCALM2_HUMANBioGRID21102557 details
S61A1_HUMANCALM3_HUMANBioGRID21102557 details
S61A1_HUMANTNFA_HUMANBioGRID24497544 details
S61A1_HUMANSC61G_HUMANBioGRID24497544 details
S61A1_HUMANS13A1_HUMANBioGRID18407958 details
S61A1_HUMANPTEN_HUMANBioGRID31685992 details
S61A1_HUMANTNR1A_HUMANIntAct14743216 details
S61A1_HUMANTNR1B_HUMANIntAct14743216 details
S61A1_HUMANTP4A3_HUMANIntAct17353931 details
S61A1_HUMANAAKB1_HUMANIntAct17353931 details
S61A1_HUMANT22D1_HUMANIntAct17353931 details
S61A1_HUMANCALX_HUMANBioGRID, IntAct, MINT22314232 29568061 details
S61A1_HUMANAPOB_HUMANBioGRID9565615 details
S61A1_HUMANHLAA_HUMANBioGRID14644099 details
S61A1_HUMANPDIA3_HUMANBioGRID14644099 details
S61A1_HUMANBAP31_HUMANBioGRID18555783 details
S61A1_HUMANSC61B_HUMANBioGRID18555783 26085089 32788342 34079125 9585408 details
S61A1_HUMANOPRD_HUMANBioGRID11054417 details
S61A1_HUMANEGFR_HUMANBioGRID20937808 23956138 25754235 details
S61A1_HUMANSYVN1_HUMANBioGRID29743537 details
S61A1_HUMANDERL1_HUMANBioGRID29743537 details
S61A1_HUMANDERL2_HUMANBioGRID29743537 details
S61A1_HUMANDERL3_HUMANBioGRID29743537 details
S61A1_HUMANERN1_HUMANBioGRID28504640 details
S61A1_HUMANRL26_HUMANBioGRID30626644 details
S61A1_HUMANS61A1_HUMANHPRD10601334 details
S61A1_HUMANSERP1_HUMANHPRD10601334 details