Entity Details

Primary name LRP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP98164
EntryNameLRP2_HUMAN
FullNameLow-density lipoprotein receptor-related protein 2
TaxID9606
Evidenceevidence at protein level
Length4655
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesLRP2

GO terms

Show/Hide Table
GOName
GO:0001523 retinoid metabolic process
GO:0001822 kidney development
GO:0001843 neural tube closure
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003223 ventricular compact myocardium morphogenesis
GO:0003281 ventricular septum development
GO:0005509 calcium ion binding
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007605 sensory perception of sound
GO:0008283 cell population proliferation
GO:0008584 male gonad development
GO:0009897 external side of plasma membrane
GO:0015031 protein transport
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0017124 SH3 domain binding
GO:0030001 metal ion transport
GO:0030424 axon
GO:0030425 dendrite
GO:0030514 negative regulation of BMP signaling pathway
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030900 forebrain development
GO:0031526 brush border membrane
GO:0031904 endosome lumen
GO:0031994 insulin-like growth factor I binding
GO:0035904 aorta development
GO:0042359 vitamin D metabolic process
GO:0042562 hormone binding
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0044321 response to leptin
GO:0045056 transcytosis
GO:0050769 positive regulation of neurogenesis
GO:0051087 chaperone binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0060068 vagina development
GO:0060982 coronary artery morphogenesis
GO:0061024 membrane organization
GO:0061156 pulmonary artery morphogenesis
GO:0070062 extracellular exosome
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation
GO:0071363 cellular response to growth factor stimulus
GO:0097242 amyloid-beta clearance
GO:0140058 neuron projection arborization
GO:0140318 protein transporter activity
GO:0150104 transport across blood-brain barrier
GO:1904447 folate import across plasma membrane
GO:1905167 positive regulation of lysosomal protein catabolic process

Subcellular Location

Show/Hide Table
Subcellular Location
Apical cell membrane
Cell projection
Endosome lumen
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR019825 Legume lectin, beta chain, Mn/Ca-binding siteSiteBinding site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
222448 OMIMDonnai-Barrow syndrome (DBS)Rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g., agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00013 UrokinaseDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech
DB00115 CyanocobalaminDrugbanksmall molecule
DB00798 GentamicinDrugbanksmall molecule

Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
LRP2_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
LRP2_HUMANABL1_HUMANIntAct17474147 details
LRP2_HUMANDAB2_HUMANBioGRID, HPRD, UniProt10769163 details
LRP2_HUMANAMRP_HUMANBioGRID, HPRD, IntAct11912251 16101684 28514442 7512726 details
LRP2_HUMANDLG3_HUMANBioGRID, HPRD12713445 details
LRP2_HUMANMAGI1_HUMANBioGRID, HPRD11274227 details
LRP2_HUMANANRA2_HUMANBioGRID, HPRD11095640 22649097 details
LRP2_HUMANLR2BP_HUMANBioGRID, HPRD12508107 details
LRP2_HUMANDLG2_HUMANBioGRID, HPRD12713445 details
LRP2_HUMANARH_HUMANBioGRID, HPRD14528014 details
LRP2_HUMANDLG4_HUMANBioGRID, HPRD10827173 12713445 details
LRP2_HUMANJIP1_HUMANBioGRID, HPRD10827173 12508107 details
LRP2_HUMANSYJ2B_HUMANBioGRID, HPRD10827173 details
LRP2_HUMANCAPON_HUMANBioGRID, HPRD10827173 details
LRP2_HUMANSCN3A_HUMANBioGRID10827173 details
LRP2_HUMANAPBA2_HUMANBioGRID, HPRD10827173 details
LRP2_HUMANAPC10_HUMANBioGRID10827173 details
LRP2_HUMANDAB1_HUMANBioGRID, HPRD10827173 12508107 9837937 details
LRP2_HUMANJIP2_HUMANBioGRID, HPRD10827173 12508107 details
LRP2_HUMANITBP1_HUMANBioGRID, HPRD10827173 details
LRP2_HUMANGIPC1_HUMANBioGRID, HPRD10827173 11912251 12508107 16908842 details
LRP2_HUMANANS1B_HUMANBioGRID, HPRD12508107 details
LRP2_HUMANRET1_HUMANBioGRID, HPRD10203351 details
LRP2_HUMANAPOH_HUMANBioGRID, HPRD9727058 details
LRP2_HUMANUTER_HUMANBioGRID, HPRD11278724 details
LRP2_HUMANLIPL_HUMANBioGRID, HPRD7686151 details
LRP2_HUMANUROK_HUMANBioGRID, HPRD8344937 details
LRP2_HUMANCLUS_HUMANBioGRID, HPRD17260971 7768901 9228033 details
LRP2_HUMANAPOE_HUMANBioGRID, HPRD11421580 7768901 details
LRP2_HUMANSNX17_HUMANBioGRID12169628 details
LRP2_HUMANTSP1_HUMANBioGRID7775583 details
LRP2_HUMANA4_HUMANBioGRID9228033 details
LRP2_HUMANRAC1_HUMANBioGRID18426980 details
LRP2_HUMANRHOA_HUMANBioGRID18426980 details
LRP2_HUMANCDC42_HUMANBioGRID18426980 details
LRP2_HUMANTLN1_HUMANHPRD10827173 details
LRP2_HUMANGASP1_HUMANHPRD11274227 details
LRP2_HUMANLRP2_HUMANHPRD11095640 12713445 details
LRP2_HUMANDLG1_HUMANHPRD12713445 details
LRP2_HUMANAPBB1_HUMANHPRD9837937 details
LRP2_HUMANPI51C_HUMANHPRD10827173 details
LRP2_HUMANCTNB1_HUMANIntAct20195357 details
LRP2_HUMANOCRL_HUMANMINT21971085 details
LRP2_HUMANEEA1_HUMANMINT21971085 details
LRP2_HUMANMPRD_HUMANMINT21971085 details
LRP2_HUMANDP13A_HUMANMINT21971085 details
LRP2_HUMANVTDB_HUMANBioGRID, HPRD11717447 details
LRP2_HUMANPAI1_HUMANHPRD8344937 details
LRP2_HUMANTTHY_HUMANHPRD10982792 details
LRP2_HUMANINS_HUMANHPRD9773776 details
LRP2_HUMANAPOB_HUMANHPRD10330424 details
LRP2_HUMANSL9A3_HUMANHPRD10364184 details
LRP2_HUMANTHYG_HUMANHPRD9492085 details
LRP2_HUMANCUBN_HUMANHPRD11595644 11994745 details
LRP2_HUMANNGAL_HUMANHPRD15670845 details
LRP2_HUMANALBU_HUMANHPRD11158855 8898021 details
LRP2_HUMANMK_HUMANHPRD10772929 details