Entity Details

Primary name RL18_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07020
EntryNameRL18_HUMAN
FullName60S ribosomal protein L18
TaxID9606
Evidenceevidence at protein level
Length188
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesRPL18

GO terms

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GOName
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002181 cytoplasmic translation
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0016020 membrane
GO:0019083 viral transcription
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0042788 polysomal ribosome

Subcellular Location

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Subcellular Location
Cytoplasm
Rough endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000039 Ribosomal protein L18eFamilyFamily
IPR021131 Ribosomal protein L18e/L15PDomainDomain
IPR021132 Ribosomal protein L18e, conserved siteSiteConserved site
IPR036227 Ribosomal L18e/L15P superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618310 OMIMDiamond-Blackfan anemia 18 (DBA18)A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. DBA18 inheritance is autosomal dominant. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11638 ArtenimolDrugbanksmall molecule