Entity Details

Primary name CUL4B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13620
EntryNameCUL4B_HUMAN
FullNameCullin-4B
TaxID9606
Evidenceevidence at protein level
Length913
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCUL4B

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000715 nucleotide-excision repair, DNA damage recognition
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006974 cellular response to DNA damage stimulus
GO:0010498 proteasomal protein catabolic process
GO:0016567 protein ubiquitination
GO:0019005 SCF ubiquitin ligase complex
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0031625 ubiquitin protein ligase binding
GO:0033683 nucleotide-excision repair, DNA incision
GO:0035518 histone H2A monoubiquitination
GO:0042254 ribosome biogenesis
GO:0042769 DNA damage response, detection of DNA damage
GO:0043687 post-translational protein modification
GO:0070062 extracellular exosome
GO:0070911 global genome nucleotide-excision repair
GO:0070914 UV-damage excision repair
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001373 Cullin, N-terminalDomainDomain
IPR016157 Cullin, conserved siteSiteConserved site
IPR016158 Cullin homology domainDomainDomain
IPR016159 Cullin repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019559 Cullin protein, neddylation domainDomainDomain
IPR033044 Cullin-4BFamilyFamily
IPR036317 Cullin homology domain superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300354 OMIMMental retardation, X-linked, syndromic, 15 (MRXS15)A syndromic form of X-linked mental retardation characterized by severe intellectual deficit associated with short stature, craniofacial dysmorphism, small testes, muscle wasting in lower legs, kyphosis, joint hyperextensibility, pes cavus, small feet, and abnormalities of the toes. Additional neurologic manifestations include speech delay and impairment, tremor, seizures, gait ataxia, hyperactivity and decreased attention span. The disease is caused by variants affecting the gene represented in this entry.

Interactions

129 interactions

InteractorPartnerSourcesPublicationsLink
CUL4B_HUMANCAND1_HUMANBioGRID, DIP, HPRD, IntAct12504026 12609982 21145461 25435324 26496610 28225217 31973889 details
CUL4B_HUMANRBX1_HUMANBioGRID, HPRD, IntAct12481031 12609982 19250909 23238014 24292684 25189618 26496610 27113764 28446751 29499938 30349055 30945288 31973889 32140073 details
CUL4B_HUMANDDB1_HUMANBioGRID, DIP, HPRD, IntAct16678110 16861906 16949367 16964240 17041588 17392787 18593899 19651607 21145461 22939629 23238014 24292684 25189618 26344197 26496610 27113764 28225217 28446751 28886238 29499938 29738775 29846670 30898011 30945288 31911655 31973889 32140073 details
CUL4B_HUMANDTL_HUMANBioGRID, IntAct16861906 16949367 17041588 21145461 21628527 23555860 24962565 26496610 31155351 31973889 details
CUL4B_HUMANCUL4A_HUMANBioGRID, IntAct16964240 17041588 18593899 21145461 23555860 30945288 31973889 32140073 details
CUL4B_HUMANDDB2_HUMANBioGRID, HPRD, IntAct16949367 17041588 18593899 21145461 26186194 26496610 28514442 30923324 30945288 31973889 details
CUL4B_HUMANNEDD8_HUMANBioGRID, HPRD, IntAct, MINT16503656 16620772 18274552 21145461 31973889 details
CUL4B_HUMANCSN5_HUMANBioGRID, IntAct18850735 19295130 19615732 21145461 23238014 23357576 26186194 26496610 28514442 30945288 31973889 details
CUL4B_HUMANPTEN_HUMANBioGRID, IntAct23238014 29499938 details
CUL4B_HUMANDCNL1_HUMANBioGRID, DIP, IntAct18826954 19617556 21145461 23201271 26906416 30587576 31973889 details
CUL4B_HUMANDCAF1_HUMANBioGRID, IntAct16949367 21145461 26496610 28416635 31973889 details
CUL4B_HUMANPRDX3_HUMANBioGRID, IntAct21145461 21795677 28225217 details
CUL4B_HUMANPHIP_HUMANBioGRID, IntAct16949367 21145461 26496610 29089422 30018425 31911655 31973889 details
CUL4B_HUMANIMA5_HUMANBioGRID, IntAct19801544 21145461 details
CUL4B_HUMANERCC8_HUMANBioGRID, IntAct21145461 22902626 26496610 29531219 31973889 details
CUL4B_HUMANCSN2_HUMANBioGRID, IntAct, MINT16861906 21145461 24981860 26186194 26496610 28514442 31973889 details
CUL4B_HUMANDCA16_HUMANBioGRID, IntAct21145461 31973889 details
CUL4B_HUMANDCAF8_HUMANBioGRID, IntAct16949367 21145461 28514442 31155351 31973889 details
CUL4B_HUMANDCA12_HUMANBioGRID, IntAct21145461 31973889 details
CUL4B_HUMANDCA10_HUMANBioGRID, IntAct21145461 26496610 31973889 details
CUL4B_HUMANDCA11_HUMANBioGRID, IntAct16949367 21145461 26496610 28446751 28514442 31155351 31973889 details
CUL4B_HUMANDCAF5_HUMANBioGRID, IntAct21145461 31973889 details
CUL4B_HUMANDCAF4_HUMANBioGRID, IntAct16949367 21145461 26496610 28446751 28514442 30945288 31973889 32140073 details
CUL4B_HUMANDCAF6_HUMANBioGRID, IntAct16949367 21145461 31973889 details
CUL4B_HUMANDDA1_HUMANBioGRID, IntAct16949367 19295130 21145461 26496610 31973889 details
CUL4B_HUMANCRBN_HUMANBioGRID, IntAct21145461 24292625 27142104 27294876 28514442 31973889 details
CUL4B_HUMANAMRA1_HUMANBioGRID, IntAct16949367 21145461 25499913 30166453 31155351 31973889 details
CUL4B_HUMANTP4AP_HUMANBioGRID, IntAct21145461 28514442 31973889 details
CUL4B_HUMANBRWD3_HUMANBioGRID, IntAct26496610 31753913 31973889 details
CUL4B_HUMANZMAT4_HUMANBioGRID, IntAct25910212 details
CUL4B_HUMANDET1_HUMANBioGRID, IntAct16949367 28514442 31973889 details
CUL4B_HUMANWDTC1_HUMANBioGRID, IntAct27113764 28514442 31973889 details
CUL4B_HUMANGLMN_HUMANBioGRID, IntAct28514442 31973889 details
CUL4B_HUMANDCNL2_HUMANBioGRID, DIP19617556 23201271 26906416 details
CUL4B_HUMANCOP1_HUMANBioGRID17041588 19295130 31973889 details
CUL4B_HUMANCOMD1_HUMANBioGRID21778237 details
CUL4B_HUMANIMA1_HUMANBioGRID19801544 details
CUL4B_HUMANIMA3_HUMANBioGRID19801544 details
CUL4B_HUMANIMB1_HUMANBioGRID19801544 details
CUL4B_HUMANSALL2_HUMANBioGRID21228219 details
CUL4B_HUMANUBC_HUMANBioGRID21145461 23314748 details
CUL4B_HUMANA4_HUMANBioGRID21832049 details
CUL4B_HUMANDCNL3_HUMANBioGRID23201271 26906416 details
CUL4B_HUMANDCNL4_HUMANBioGRID23201271 details
CUL4B_HUMANDCNL5_HUMANBioGRID23201271 26906416 details
CUL4B_HUMANSIN3A_HUMANBioGRID25189618 details
CUL4B_HUMANDCA17_HUMANBioGRID16949367 31973889 details
CUL4B_HUMANRBX2_HUMANBioGRID19250909 details
CUL4B_HUMANHUWE1_HUMANBioGRID25883150 details
CUL4B_HUMANUB2D3_HUMANBioGRID21795677 details
CUL4B_HUMANDNM3A_HUMANBioGRID24292684 details
CUL4B_HUMANSUV91_HUMANBioGRID24292684 details
CUL4B_HUMANDNMT1_HUMANBioGRID24292684 29691401 details
CUL4B_HUMANDNM3B_HUMANBioGRID24292684 details
CUL4B_HUMANAHR_HUMANBioGRID, HPRD17392787 details
CUL4B_HUMANTBL3_HUMANBioGRID17392787 details
CUL4B_HUMANCUL4B_HUMANBioGRID17392787 30945288 31973889 details
CUL4B_HUMANDCA15_HUMANBioGRID31452512 31973889 details
CUL4B_HUMANST7_HUMANBioGRID30945288 details
CUL4B_HUMANOXSR1_HUMANBioGRID31614064 details
CUL4B_HUMANBRWD1_HUMANBioGRID31973889 details
CUL4B_HUMANPWP1_HUMANBioGRID31973889 details
CUL4B_HUMANWDR5_HUMANBioGRID, IntAct17041588 31155351 details
CUL4B_HUMANUBXN7_HUMANBioGRID, DIP, IntAct18775313 22466964 31973889 details
CUL4B_HUMANANM5_HUMANBioGRID, IntAct20951943 24292684 29846670 details
CUL4B_HUMANHS90B_HUMANBioGRID, IntAct21145461 22939624 details
CUL4B_HUMANCDC37_HUMANIntAct22939624 25036637 details
CUL4B_HUMANEZH2_HUMANBioGRID, IntAct23238014 24292684 27634302 details
CUL4B_HUMANPHF1_HUMANBioGRID, IntAct23238014 29846670 details
CUL4B_HUMANCSN4_HUMANBioGRID, IntAct, MINT19295130 21145461 23238014 24292684 24981860 26496610 28225217 31973889 details
CUL4B_HUMANCSN3_HUMANBioGRID, IntAct, MINT16036220 19295130 21145461 22863883 23238014 24981860 26186194 26496610 28514442 31973889 details
CUL4B_HUMANHS90A_HUMANBioGRID, IntAct21145461 22939624 details
CUL4B_HUMANCSN1_HUMANBioGRID, IntAct16861906 21145461 26496610 31973889 details
CUL4B_HUMANCSN8_HUMANBioGRID, IntAct, MINT21145461 24981860 26496610 27173435 28514442 31973889 unassigned1312 details
CUL4B_HUMANDCAF7_HUMANBioGRID, IntAct21145461 31155351 details
CUL4B_HUMANDISC1_HUMANIntAct31413325 details
CUL4B_HUMANRBBP5_HUMANBioGRID17041588 details
CUL4B_HUMANWDR5B_HUMANBioGRID17041588 details
CUL4B_HUMANPOC1B_HUMANBioGRID17041588 details
CUL4B_HUMANSNR40_HUMANBioGRID17041588 details
CUL4B_HUMANWDR61_HUMANBioGRID17041588 details
CUL4B_HUMANWDR76_HUMANBioGRID17041588 details
CUL4B_HUMANSIR7_HUMANBioGRID22586326 28886238 details
CUL4B_HUMANCDT1_HUMANBioGRID14578910 details
CUL4B_HUMANCCNE1_HUMANBioGRID16322693 details
CUL4B_HUMANPCNA_HUMANBioGRID16861890 details
CUL4B_HUMANMDM2_HUMANBioGRID22032989 28225217 details
CUL4B_HUMANERPG3_HUMANBioGRID22032989 details
CUL4B_HUMANERCC6_HUMANBioGRID22032989 details
CUL4B_HUMANGRK5_HUMANBioGRID22952844 details
CUL4B_HUMANRPTOR_HUMANBioGRID23297343 31825840 details
CUL4B_HUMANMS18B_HUMANBioGRID24269809 details
CUL4B_HUMANP53_HUMANBioGRID24452595 31570706 details
CUL4B_HUMANNR2C2_HUMANBioGRID24703702 details
CUL4B_HUMANHDAC1_HUMANBioGRID25189618 details
CUL4B_HUMANHDAC2_HUMANBioGRID25189618 30737378 details
CUL4B_HUMANARI4B_HUMANBioGRID25189618 details
CUL4B_HUMANSP130_HUMANBioGRID25189618 details
CUL4B_HUMANSDS3_HUMANBioGRID25189618 details
CUL4B_HUMANSAP30_HUMANBioGRID25189618 details
CUL4B_HUMANRET1_HUMANBioGRID25189618 details
CUL4B_HUMANCLCN1_HUMANBioGRID26021757 details
CUL4B_HUMANTBG1_HUMANBioGRID25542213 details
CUL4B_HUMANFBX44_HUMANBioGRID25970626 details
CUL4B_HUMANWDR62_HUMANBioGRID25385192 details
CUL4B_HUMANRBBP7_HUMANBioGRID25795299 29738775 details
CUL4B_HUMANENPL_HUMANBioGRID27580824 details
CUL4B_HUMANFKBP8_HUMANBioGRID27580824 details
CUL4B_HUMANCBX5_HUMANBioGRID24292684 details
CUL4B_HUMANCBX1_HUMANBioGRID24292684 details
CUL4B_HUMANCBX3_HUMANBioGRID24292684 details
CUL4B_HUMANNSD1_HUMANBioGRID24292684 details
CUL4B_HUMANNU160_HUMANBioGRID24292684 details
CUL4B_HUMANSMYD2_HUMANBioGRID24292684 details
CUL4B_HUMANESR1_HUMANBioGRID, HPRD17392787 details
CUL4B_HUMANRGS2_HUMANBioGRID28974581 details
CUL4B_HUMANRBM39_HUMANBioGRID28225217 28302793 details
CUL4B_HUMANMEP50_HUMANBioGRID29846670 details
CUL4B_HUMANESCO2_HUMANBioGRID30779731 details
CUL4B_HUMANRORG_HUMANBioGRID30992047 details
CUL4B_HUMANWIPI2_HUMANBioGRID30898011 details
CUL4B_HUMANAPAF_HUMANBioGRID31329620 details
CUL4B_HUMANBUB3_HUMANBioGRID31911655 details
CUL4B_HUMANSHLD2_HUMANBioGRID30154076 details
CUL4B_HUMANCLCN2_HUMANBioGRID32466489 details
CUL4B_HUMANMPIP1_HUMANBioGRID27462461 details
CUL4B_HUMANMERL_HUMANBioGRID33058421 details
CUL4B_HUMANSOX9_HUMANBioGRID33173725 details
CUL4B_HUMANANDR_HUMANHPRD17392787 details