Entity Details

Primary name KYNU_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16719
EntryNameKYNU_HUMAN
FullNameKynureninase
TaxID9606
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesKYNU

GO terms

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GOName
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006569 tryptophan catabolic process
GO:0007568 aging
GO:0009435 NAD biosynthetic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019442 tryptophan catabolic process to acetyl-CoA
GO:0019805 quinolinate biosynthetic process
GO:0030170 pyridoxal phosphate binding
GO:0030429 kynureninase activity
GO:0034341 response to interferon-gamma
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0034516 response to vitamin B6
GO:0042803 protein homodimerization activity
GO:0043420 anthranilate metabolic process
GO:0061981 3-hydroxykynureninase activity
GO:0097053 L-kynurenine catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000192 Aminotransferase class V domainDomainDomain
IPR010111 KynureninaseFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
236800 OMIMHydroxykynureninuria (HYXKY)An inborn error of amino acid metabolism characterized by massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid. Affected individuals manifest renal tubular dysfunction, metabolic acidosis, psychomotor retardation, non-progressive encephalopathy, and muscular hypertonia. The disease is caused by variants affecting the gene represented in this entry.
617661 OMIMVertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2)An autosomal recessive congenital malformation syndrome characterized by vertebral segmentation abnormalities, congenital cardiac defects, renal defects, and distal mild limb defects. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00160 AlanineDrugbanksmall molecule
DB07069 m-Hydroxyhippuric acidDrugbanksmall molecule

Interactions

9 interactions