Entity Details

Primary name PRKCH
Entity type gene
Source Source Link

Details

PrimaryID5583
RefseqGeneNG_011514
SymbolPRKCH
Nameprotein kinase C eta
Chromosome14
Location14q23.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-25
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsKPCL_HUMAN

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0018105 peptidyl-serine phosphorylation
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035556 intracellular signal transduction
GO:0045618 positive regulation of keratinocyte differentiation
GO:0046872 metal ion binding
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060252 positive regulation of glial cell proliferation
GO:0070062 extracellular exosome
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:2000810 regulation of bicellular tight junction assembly

Diseases

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Disease IDSourceNameDescription
601367 OMIMIschemic stroke (ISCHSTR)A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Disease susceptibility is associated with variants affecting the gene represented in this entry.