Entity Details

Primary name GREM2
Entity type gene
Source Source Link

Details

PrimaryID64388
RefseqGeneNG_053136
SymbolGREM2
Namegremlin 2, DAN family BMP antagonist
Chromosome1
Location1q43
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-02-13
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGREM2_HUMAN

GO terms

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GOName
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0008201 heparin binding
GO:0009887 animal organ morphogenesis
GO:0010172 embryonic body morphogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0036122 BMP binding
GO:0038098 sequestering of BMP from receptor via BMP binding
GO:0048018 receptor ligand activity
GO:0060300 regulation of cytokine activity

Diseases

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Disease IDSourceNameDescription
617275 OMIMTooth agenesis, selective, 9 (STHAG9)A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG9 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GREM2BMP2HPRD15039429 details
GREM2BMP4HPRD15039429 details
GREM2AGO2BioGRID29955039 details