Entity Details

Primary name TPO
Entity type gene
Source Source Link

Details

PrimaryID7173
RefseqGeneNG_011581
SymbolTPO
Namethyroid peroxidase
Chromosome2
Location2p25.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1988-05-11
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPERT_HUMAN

GO terms

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GOName
GO:0004447 iodide peroxidase activity
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006590 thyroid hormone generation
GO:0006979 response to oxidative stress
GO:0009986 cell surface
GO:0020037 heme binding
GO:0035162 embryonic hemopoiesis
GO:0042446 hormone biosynthetic process
GO:0042744 hydrogen peroxide catabolic process

Diseases

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Disease IDSourceNameDescription
274500 OMIMThyroid dyshormonogenesis 2A (TDH2A)A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
TPOTXNDC11HPRD15561711 details
TPODUOX1HPRD15561711 details
TPOFOXE1IntAct27852061 details
TPOELK1IntAct27852061 details