Entity Details

Primary name NR4A3
Entity type gene
Source Source Link

Details

PrimaryID8013
RefseqGeneNG_028910
SymbolNR4A3
Namenuclear receptor subfamily 4 group A member 3
Chromosome9
Location9q31.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-22
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsNR4A3_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007369 gastrulation
GO:0008270 zinc ion binding
GO:0009444 pyruvate oxidation
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010828 positive regulation of glucose transmembrane transport
GO:0019901 protein kinase binding
GO:0031100 animal organ regeneration
GO:0032765 positive regulation of mast cell cytokine production
GO:0035259 glucocorticoid receptor binding
GO:0035497 cAMP response element binding
GO:0035726 common myeloid progenitor cell proliferation
GO:0038097 positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0043303 mast cell degranulation
GO:0044320 cellular response to leptin stimulus
GO:0045333 cellular respiration
GO:0045444 fat cell differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0061469 regulation of type B pancreatic cell proliferation
GO:0071376 cellular response to corticotropin-releasing hormone stimulus
GO:0071870 cellular response to catecholamine stimulus
GO:0097009 energy homeostasis
GO:1900625 positive regulation of monocyte aggregation
GO:1903208 negative regulation of hydrogen peroxide-induced neuron death
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:2000253 positive regulation of feeding behavior

Diseases

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Disease IDSourceNameDescription
612219 OMIMEwing sarcoma (ES)A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
NR4A3KRTAP5-6BioGRID, IntAct32296183 details
NR4A3PCSK5BioGRID, IntAct32296183 details
NR4A3KPRPBioGRID, IntAct32296183 details
NR4A3LCE2BBioGRID, IntAct32296183 details
NR4A3KRTAP9-2BioGRID, IntAct32296183 details
NR4A3UBE3ABioGRID, IntAct32296183 details
NR4A3LCE2DBioGRID, IntAct32296183 details
NR4A3CDKN2DBioGRID, IntAct32296183 details
NR4A3SMOC1BioGRID, IntAct32296183 details
NR4A3NECTIN2BioGRID, IntAct32296183 details
NR4A3KRTAP4-11BioGRID, IntAct32296183 details
NR4A3CYSRT1BioGRID, IntAct32296183 details
NR4A3MACO1BioGRID, IntAct32296183 details
NR4A3KRTAP4-4BioGRID, IntAct32296183 details
NR4A3VASNBioGRID, IntAct32296183 details
NR4A3ALPPBioGRID, IntAct32296183 details
NR4A3TSPAN4BioGRID, IntAct32296183 details
NR4A3KRTAP12-4BioGRID, IntAct32296183 details
NR4A3PIN1BioGRID, IntAct32296183 details
NR4A3CHRDBioGRID, IntAct32296183 details
NR4A3KRTAP5-9BioGRID, IntAct32296183 details
NR4A3KRTAP9-8BioGRID, IntAct32296183 details
NR4A3KRTAP5-11BioGRID, IntAct32296183 details
NR4A3ZNF330BioGRID, IntAct32296183 details
NR4A3VWC2LBioGRID, IntAct32296183 details
NR4A3HSD3B7BioGRID, IntAct32296183 details
NR4A3KRTAP12-3BioGRID, IntAct32296183 details
NR4A3ADAMTSL4BioGRID, IntAct32296183 details
NR4A3KRTAP4-2BioGRID, IntAct32296183 details
NR4A3EFEMP1BioGRID, IntAct32296183 details
NR4A3KRTAP5-3BioGRID, IntAct32296183 details
NR4A3KRTAP9-3BioGRID, IntAct32296183 details
NR4A3KRTAP10-8BioGRID, IntAct32296183 details
NR4A3SIX3BioGRID, HPRD, UniProt11173923 12543801 15523651 details
NR4A3TRIM28BioGRID19321449 details
NR4A3COPS5BioGRID, HPRD15604093 details
NR4A3RECKBioGRID32296183 details
NR4A3KRTAP10-1BioGRID32296183 details
NR4A3CYP21A2BioGRID32296183 details
NR4A3BCL2MINT30455429 details
NR4A3KDM5BBioGRID19336002 details
NR4A3RPS6KA1HPRD16223362 details
NR4A3VHLHPRD18305400 details
NR4A3RNF4BioGRID29180619 details
NR4A3NR3C1BioGRID31182584 details
NR4A3VIRMABioGRID29507755 details