Entity Details

Primary name EPX
Entity type gene
Source Source Link

Details

PrimaryID8288
RefseqGeneNG_013020
SymbolEPX
Nameeosinophil peroxidase
Chromosome17
Location17q22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-11-23
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPERE_HUMAN

GO terms

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GOName
GO:0002215 defense response to nematode
GO:0004601 peroxidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006979 response to oxidative stress
GO:0020037 heme binding
GO:0032693 negative regulation of interleukin-10 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032753 positive regulation of interleukin-4 production
GO:0034774 secretory granule lumen
GO:0042742 defense response to bacterium
GO:0042744 hydrogen peroxide catabolic process
GO:0043312 neutrophil degranulation
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:0072677 eosinophil migration

Diseases

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Disease IDSourceNameDescription
261500 OMIMEosinophil peroxidase deficiency (EPXD)A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils. The disease is caused by variants affecting the gene represented in this entry.

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
EPXNCK1IntAct17474147 details
EPXPIK3R1IntAct17474147 details
EPXPLCG1IntAct17474147 details
EPXGANBioGRID26460568 details
EPXTMEM237BioGRID, IntAct26186194 28514442 details