Entity Details

Primary name PLCZ1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86YW0
EntryNamePLCZ1_HUMAN
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
TaxID9606
Evidenceevidence at protein level
Length608
SequenceStatuscomplete
DateCreated2008-09-02
DateModified2021-06-02

Ontological Relatives

GenesPLCZ1

GO terms

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GOName
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007275 multicellular organism development
GO:0007343 egg activation
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0016042 lipid catabolic process
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0043647 inositol phosphate metabolic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0060470 positive regulation of cytosolic calcium ion concentration involved in egg activation
GO:0061827 sperm head

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domainDomainDomain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR028395 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1FamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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