Entity Details

Primary name SPB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IY81
EntryNameSPB1_HUMAN
FullNamepre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
TaxID9606
Evidenceevidence at protein level
Length847
SequenceStatuscomplete
DateCreated2005-08-16
DateModified2021-06-02

Ontological Relatives

GenesFTSJ3

GO terms

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GOName
GO:0000453 enzyme-directed rRNA 2'-O-methylation
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001510 RNA methylation
GO:0003723 RNA binding
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0008173 RNA methyltransferase activity
GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity
GO:0016435 rRNA (guanine) methyltransferase activity
GO:0030687 preribosome, large subunit precursor
GO:0030688 preribosome, small subunit precursor
GO:0031167 rRNA methylation
GO:0062105 RNA 2'-O-methyltransferase activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002877 Ribosomal RNA methyltransferase FtsJ domainDomainDomain
IPR012920 Ribosomal RNA methyltransferase, Spb1, C-terminalDomainDomain
IPR015507 Ribosomal RNA large subunit methyltransferase EFamilyFamily
IPR024576 Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381DomainDomain
IPR028589 AdoMet-dependent rRNA methyltransferase Spb1-likeFamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily

Diseases

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