Entity Details

Primary name SFRP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N474
EntryNameSFRP1_HUMAN
FullNameSecreted frizzled-related protein 1
TaxID9606
Evidenceevidence at protein level
Length314
SequenceStatuscomplete
DateCreated2005-03-15
DateModified2021-06-02

Ontological Relatives

GenesSFRP1

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002244 hematopoietic progenitor cell differentiation
GO:0004197 cysteine-type endopeptidase activity
GO:0005109 frizzled binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009267 cellular response to starvation
GO:0009950 dorsal/ventral axis specification
GO:0009986 cell surface
GO:0010564 regulation of cell cycle process
GO:0010629 negative regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010975 regulation of neuron projection development
GO:0014034 neural crest cell fate commitment
GO:0014070 response to organic cyclic compound
GO:0017147 Wnt-protein binding
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030514 negative regulation of BMP signaling pathway
GO:0033689 negative regulation of osteoblast proliferation
GO:0035019 somatic stem cell population maintenance
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043508 negative regulation of JUN kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044345 stromal-epithelial cell signaling involved in prostate gland development
GO:0045578 negative regulation of B cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045765 regulation of angiogenesis
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046676 negative regulation of insulin secretion
GO:0046851 negative regulation of bone remodeling
GO:0048147 negative regulation of fibroblast proliferation
GO:0048546 digestive tract morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060070 canonical Wnt signaling pathway
GO:0060218 hematopoietic stem cell differentiation
GO:0060346 bone trabecula formation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071305 cellular response to vitamin D
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071391 cellular response to estrogen stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071481 cellular response to X-ray
GO:0071504 cellular response to heparin
GO:0071542 dopaminergic neuron differentiation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071773 cellular response to BMP stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090246 convergent extension involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904956 regulation of midbrain dopaminergic neuron differentiation
GO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000052 positive regulation of non-canonical Wnt signaling pathway
GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:2000080 negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000271 positive regulation of fibroblast apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR015526 Frizzled/secreted frizzled-related proteinFamilyFamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR026559 Secreted frizzled-related protein 1FamilyFamily
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR041760 SFRP1, cysteine-rich domainDomainDomain

Diseases

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