Entity Details

Primary name PDE2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00408
EntryNamePDE2A_HUMAN
FullNamecGMP-dependent 3',5'-cyclic phosphodiesterase
TaxID9606
Evidenceevidence at protein level
Length941
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPDE2A

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000287 magnesium ion binding
GO:0003170 heart valve development
GO:0003281 ventricular septum development
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0010752 regulation of cGMP-mediated signaling
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0010821 regulation of mitochondrion organization
GO:0019933 cAMP-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0030224 monocyte differentiation
GO:0030552 cAMP binding
GO:0030553 cGMP binding
GO:0030911 TPR domain binding
GO:0035690 cellular response to drug
GO:0035904 aorta development
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0042301 phosphate ion binding
GO:0042734 presynaptic membrane
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043116 negative regulation of vascular permeability
GO:0043117 positive regulation of vascular permeability
GO:0043949 regulation of cAMP-mediated signaling
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0046069 cGMP catabolic process
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048471 perinuclear region of cytoplasm
GO:0050729 positive regulation of inflammatory response
GO:0061028 establishment of endothelial barrier
GO:0071260 cellular response to mechanical stimulus
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097060 synaptic membrane
GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Mitochondrion
Mitochondrion inner membrane
Mitochondrion matrix
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003018 GAF domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR029016 GAF-like domain superfamilyFamilyHomologous superfamily
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB02315 Cyclic GMPDrugbanksmall molecule
DB05142 ND7001Drugbanksmall molecule
DB06246 ExisulindDrugbanksmall molecule
DB07954 3-isobutyl-1-methyl-7H-xanthineDrugbanksmall molecule
DB08811 TofisopamDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule

Interactions

3 interactions