Entity Details

Primary name KRIT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00522
EntryNameKRIT1_HUMAN
FullNameKrev interaction trapped protein 1
TaxID9606
Evidenceevidence at protein level
Length736
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesKRIT1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0007264 small GTPase mediated signal transduction
GO:0008017 microtubule binding
GO:0010596 negative regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0030695 GTPase regulator activity
GO:0045454 cell redox homeostasis
GO:2000114 regulation of establishment of cell polarity
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR032022 KRIT, N-terminal NPxY motif-rich regionDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR041791 Krev interaction trapped protein 1, FERM domain C-lobeDomainDomain
IPR043058 KRIT, N-terminal NPxY motif-rich domain superfamilyFamilyHomologous superfamily

Diseases

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