Entity Details

Primary name ESR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92731
EntryNameESR2_HUMAN
FullNameEstrogen receptor beta
TaxID9606
Evidenceevidence at protein level
Length530
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesESR2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005496 steroid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0030284 estrogen receptor activity
GO:0030308 negative regulation of cell growth
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0034056 estrogen response element binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048019 receptor antagonist activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0071392 cellular response to estradiol stimulus

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR021064 Estrogen receptor beta, N-terminalDomainDomain
IPR024178 Estrogen receptor/oestrogen-related receptorFamilyFamily
IPR028355 Estrogen receptor beta/gammaFamilyFamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB01108 TrilostaneDrugbanksmall molecule
DB01196 EstramustineDrugbanksmall molecule
DB01428 OxybenzoneDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB01878 BenzophenoneDrugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB02757 PyrazoleDrugbanksmall molecule
DB02983 Para-Mercury-Benzenesulfonic AcidDrugbanksmall molecule
DB03467 NaringeninDrugbanksmall molecule
DB03860 ICI-164384Drugbanksmall molecule
DB03882 5-Alpha-Androstane-3-Beta,17beta-DiolDrugbanksmall molecule
DB04020 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)PhenolDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04468 AfimoxifeneDrugbanksmall molecule
DB04573 EstriolDrugbanksmall molecule
DB04574 Estrone sulfateDrugbanksmall molecule
DB05052 MF101Drugbanksmall molecule
DB05882 CHF 4227Drugbanksmall molecule
DB05966 TAS-108Drugbanksmall molecule
DB06202 LasofoxifeneDrugbanksmall molecule
DB06249 ArzoxifeneDrugbanksmall molecule
DB06401 BazedoxifeneDrugbanksmall molecule
DB06832 PrinaberelDrugbanksmall molecule
DB06875 ERB-196Drugbanksmall molecule
DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILEDrugbanksmall molecule
DB06937 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOLDrugbanksmall molecule
DB07009 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OLDrugbanksmall molecule
DB07032 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OLDrugbanksmall molecule
DB07036 (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-olDrugbanksmall molecule
DB07119 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOLDrugbanksmall molecule
DB07150 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIMEDrugbanksmall molecule
DB07198 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILEDrugbanksmall molecule
DB07230 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONEDrugbanksmall molecule
DB07236 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OLDrugbanksmall molecule
DB07638 (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OLDrugbanksmall molecule
DB07702 17alpha-EstriolDrugbanksmall molecule
DB07757 (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-oneDrugbanksmall molecule
DB07933 ErteberelDrugbanksmall molecule
DB08020 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OLDrugbanksmall molecule
DB09086 EugenolDrugbanksmall molecule
DB09535 OctocryleneDrugbanksmall molecule
DB11219 EnzacameneDrugbanksmall molecule
DB11674 EquolDrugbanksmall molecule
DB13869 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14641 Estriol tripropionateDrugbanksmall molecule
DB15690 Fluoroestradiol F-18Drugbanksmall molecule

Interactions

122 interactions

InteractorPartnerSourcesPublicationsLink
ESR2_HUMANESR2_HUMANBioGRID, DIP, HPRD, IntAct12456792 15231873 17991765 19022902 20353944 21182203 21951318 details
ESR2_HUMANMED1_HUMANBioGRID, HPRD, IntAct10770935 11500849 11867769 21182203 details
ESR2_HUMANAGR3_HUMANBioGRID, MINT25640309 details
ESR2_HUMANIL24_HUMANBioGRID, MINT25640309 details
ESR2_HUMANTSP50_HUMANBioGRID, MINT25640309 details
ESR2_HUMANPLS1_HUMANBioGRID, IntAct24722188 25416956 25910212 details
ESR2_HUMANCCD62_HUMANIntAct19126643 details
ESR2_HUMANNCOA1_HUMANBioGRID, HPRD, IntAct10731636 10809226 11014206 11376110 11500849 12554772 14715875 15604093 19126643 details
ESR2_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
ESR2_HUMANREXO4_HUMANBioGRID, HPRD10908561 29509190 details
ESR2_HUMANMED24_HUMANBioGRID, IntAct11867769 21182203 29509190 details
ESR2_HUMANKLK9_HUMANBioGRID, MINT25640309 details
ESR2_HUMANCDK8_HUMANBioGRID11867769 details
ESR2_HUMANEP300_HUMANBioGRID11500849 18765668 details
ESR2_HUMANPRGC1_HUMANBioGRID, HPRD15604093 15784253 details
ESR2_HUMANTRAM1_HUMANBioGRID11014206 29509190 details
ESR2_HUMANESR1_HUMANBioGRID, DIP, HPRD, IntAct10706629 12630920 17991765 19022902 19746436 21182203 29509190 9473491 details
ESR2_HUMANMRC2_HUMANBioGRID, MINT25640309 details
ESR2_HUMANIMA4_HUMANBioGRID, IntAct32296183 details
ESR2_HUMANPNRC1_HUMANBioGRID, HPRD15604093 details
ESR2_HUMANNCOA3_HUMANBioGRID, HPRD, IntAct10681591 11376110 11389589 11500849 12554772 17158759 21182203 9765300 details
ESR2_HUMANMED16_HUMANBioGRID, IntAct11867769 21182203 29509190 details
ESR2_HUMANLRAT2_HUMANBioGRID, MINT25640309 29509190 details
ESR2_HUMANTDIF2_HUMANBioGRID, HPRD15047147 29509190 details
ESR2_HUMANSP1_HUMANBioGRID, HPRD10681512 18765668 details
ESR2_HUMANSERPH_HUMANBioGRID11500849 details
ESR2_HUMANMED17_HUMANBioGRID, IntAct11867769 21182203 29509190 details
ESR2_HUMANMED23_HUMANBioGRID, IntAct11867769 21182203 29509190 details
ESR2_HUMANTIF1A_HUMANBioGRID, HPRD, IntAct10598587 11500849 21182203 29509190 details
ESR2_HUMANMED14_HUMANBioGRID, IntAct11867769 21182203 29509190 details
ESR2_HUMANRFOX2_HUMANBioGRID, HPRD, UniProt11875103 details
ESR2_HUMANCASC3_HUMANBioGRID, MINT25640309 29509190 details
ESR2_HUMANTRXR1_HUMANBioGRID, IntAct15199063 details
ESR2_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
ESR2_HUMANNCOA6_HUMANBioGRID, HPRD11158331 11773444 15604093 details
ESR2_HUMANMED7_HUMANBioGRID11867769 details
ESR2_HUMANNRIP1_HUMANBioGRID, HPRD, IntAct11500849 15604093 21182203 details
ESR2_HUMANCASZ1_HUMANBioGRID, MINT25640309 29509190 details
ESR2_HUMANITIH5_HUMANBioGRID, MINT25640309 details
ESR2_HUMANDDX54_HUMANBioGRID, HPRD12466272 details
ESR2_HUMANTRIP4_HUMANBioGRID11500849 29509190 details
ESR2_HUMANMEOX2_HUMANBioGRID24722188 details
ESR2_HUMANDKK3_HUMANBioGRID, MINT25640309 details
ESR2_HUMANSRC_HUMANBioGRID, HPRD11013076 11032808 12095943 12630920 details
ESR2_HUMANMKNK2_HUMANBioGRID, HPRD11013076 details
ESR2_HUMANNR0B2_HUMANHPRD10648597 9773978 details
ESR2_HUMANPPP5_HUMANBioGRID, IntAct14764652 details
ESR2_HUMANI13R2_HUMANBioGRID, MINT25640309 details
ESR2_HUMANPRS8_HUMANBioGRID, IntAct15604093 25604459 29509190 details
ESR2_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
ESR2_HUMANCCN2_HUMANMINT21629692 details
ESR2_HUMANMD2L1_HUMANBioGRID, HPRD10706629 details
ESR2_HUMANSMCE1_HUMANBioGRID, HPRD12145209 29509190 details
ESR2_HUMANNCOA2_HUMANBioGRID11014206 11376110 11500849 12554772 12630920 details
ESR2_HUMANJHD2C_HUMANBioGRID11500849 details
ESR2_HUMANNT2NA_HUMANBioGRID, IntAct24722188 details
ESR2_HUMANRFX6_HUMANBioGRID, IntAct24722188 details
ESR2_HUMAN1433T_HUMANBioGRID11266503 29509190 details
ESR2_HUMANSTA5A_HUMANBioGRID, HPRD11682624 details
ESR2_HUMANNT2NC_HUMANBioGRID24722188 details
ESR2_HUMANDNM3L_HUMANBioGRID24952347 details
ESR2_HUMANMED20_HUMANBioGRID11867769 29509190 details
ESR2_HUMANNCOR1_HUMANBioGRID, HPRD12904255 29509190 details
ESR2_HUMANMED12_HUMANBioGRID, IntAct11867769 21182203 details
ESR2_HUMANTFF1_HUMANBioGRID, MINT25640309 details
ESR2_HUMANMSH2_HUMANBioGRID15886699 29509190 details
ESR2_HUMANMK01_HUMANBioGRID11358671 details
ESR2_HUMANPNRC2_HUMANBioGRID, HPRD15604093 details
ESR2_HUMANARI5A_HUMANBioGRID, UniProt15941852 details
ESR2_HUMANPIAS2_HUMANBioGRID11117529 details
ESR2_HUMANMED6_HUMANBioGRID11867769 29509190 details
ESR2_HUMANHOP2_HUMANHPRD11739747 details
ESR2_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
ESR2_HUMANCCDB1_HUMANIntAct25910212 details
ESR2_HUMANMMS19_HUMANBioGRID, HPRD11279242 details
ESR2_HUMANCRTP1_HUMANBioGRID, IntAct29509190 32296183 details
ESR2_HUMANMDFI_HUMANIntAct25910212 details
ESR2_HUMANRT29_HUMANBioGRID10903152 29509190 details
ESR2_HUMANIKBB_HUMANBioGRID11500849 details
ESR2_HUMANMED10_HUMANBioGRID11867769 details
ESR2_HUMANRBM39_HUMANBioGRID, HPRD11704680 details
ESR2_HUMANZNHI3_HUMANBioGRID11500849 details
ESR2_HUMANSPF27_HUMANBioGRID, HPRD15694360 29509190 details
ESR2_HUMANTRI59_HUMANHPRD15941852 details
ESR2_HUMANCCNC_HUMANBioGRID11867769 details
ESR2_HUMANKLF5_HUMANBioGRID21487105 details
ESR2_HUMANSRA1_HUMANBioGRID20398657 details
ESR2_HUMANTFCP2_HUMANIntAct25910212 details
ESR2_HUMANMED21_HUMANBioGRID11867769 details
ESR2_HUMANKAT5_HUMANBioGRID11591700 details
ESR2_HUMANNCOR2_HUMANBioGRID, HPRD, IntAct12904255 14715875 29509190 details
ESR2_HUMANHS90A_HUMANBioGRID20353944 details
ESR2_HUMANCALM1_HUMANBioGRID, HPRD11981030 21951318 29509190 details
ESR2_HUMANMK11_HUMANHPRD11579095 details
ESR2_HUMANPELP1_HUMANHPRD, IntAct12415108 21182203 details
ESR2_HUMANEGFR_HUMANBioGRID, IntAct21951318 details
ESR2_HUMANBRCA1_HUMANBioGRID, IntAct21951318 details
ESR2_HUMANSMAD3_HUMANHPRD11555647 details
ESR2_HUMANNCOA7_HUMANHPRD11971969 8197458 details
ESR2_HUMANUBE3A_HUMANBioGRID17962381 25408199 details
ESR2_HUMANWIPI1_HUMANHPRD15602573 details
ESR2_HUMANCALM3_HUMANBioGRID, HPRD11981030 21951318 29509190 details
ESR2_HUMANSRBP1_HUMANHPRD12021179 details
ESR2_HUMANSMAD4_HUMANHPRD11555647 details
ESR2_HUMANCALM2_HUMANBioGRID, HPRD, IntAct11981030 21951318 25604459 29509190 details
ESR2_HUMANAKP13_HUMANBioGRID, HPRD11579095 29509190 details
ESR2_HUMANLCK_HUMANHPRD12415108 details
ESR2_HUMANFOXO3_HUMANBioGRID, IntAct18312651 29509190 details
ESR2_HUMANANM2_HUMANHPRD, IntAct12039952 details
ESR2_HUMANSMAD2_HUMANHPRD11555647 details
ESR2_HUMANCBP_HUMANBioGRID18765668 details
ESR2_HUMAN1433F_HUMANHPRD11266503 details
ESR2_HUMANNR0B1_HUMANHPRD11053406 details
ESR2_HUMANAGO2_HUMANBioGRID29509190 details
ESR2_HUMANMDM2_HUMANBioGRID22349818 details
ESR2_HUMANWWP1_HUMANBioGRID21487105 details
ESR2_HUMANPIAS3_HUMANBioGRID, HPRD11117529 29509190 details
ESR2_HUMANNEU1_HUMANHPRD9501254 details
ESR2_HUMANAKT1_HUMANHPRD15001646 details
ESR2_HUMANZBT17_HUMANHPRD11117529 details
ESR2_HUMANMYOD1_HUMANBioGRID18765668 details
ESR2_HUMANPIAS1_HUMANHPRD11117529 details