Entity Details

Primary name RYR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92736
EntryNameRYR2_HUMAN
FullNameRyanodine receptor 2
TaxID9606
Evidenceevidence at protein level
Length4967
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesRYR2

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0002027 regulation of heart rate
GO:0003143 embryonic heart tube morphogenesis
GO:0003220 left ventricular cardiac muscle tissue morphogenesis
GO:0003300 cardiac muscle hypertrophy
GO:0005219 ryanodine-sensitive calcium-release channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005513 detection of calcium ion
GO:0005516 calmodulin binding
GO:0005790 smooth endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0010460 positive regulation of heart rate
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014701 junctional sarcoplasmic reticulum membrane
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014850 response to muscle activity
GO:0015278 calcium-release channel activity
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0019722 calcium-mediated signaling
GO:0019899 enzyme binding
GO:0030018 Z disc
GO:0030659 cytoplasmic vesicle membrane
GO:0031000 response to caffeine
GO:0032991 protein-containing complex
GO:0033017 sarcoplasmic reticulum membrane
GO:0034220 ion transmembrane transport
GO:0034236 protein kinase A catalytic subunit binding
GO:0034237 protein kinase A regulatory subunit binding
GO:0034704 calcium channel complex
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0035994 response to muscle stretch
GO:0042383 sarcolemma
GO:0042802 identical protein binding
GO:0043621 protein self-association
GO:0043924 suramin binding
GO:0044325 transmembrane transporter binding
GO:0048763 calcium-induced calcium release activity
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051284 positive regulation of sequestering of calcium ion
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051775 response to redox state
GO:0055117 regulation of cardiac muscle contraction
GO:0060048 cardiac muscle contraction
GO:0060402 calcium ion transport into cytosol
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0071313 cellular response to caffeine
GO:0071872 cellular response to epinephrine stimulus
GO:0072599 establishment of protein localization to endoplasmic reticulum
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0097050 type B pancreatic cell apoptotic process
GO:0098735 positive regulation of the force of heart contraction
GO:0098904 regulation of AV node cell action potential
GO:0098907 regulation of SA node cell action potential
GO:0098910 regulation of atrial cardiac muscle cell action potential
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Membrane
Sarcoplasmic reticulum
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000699 RIH domainDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR003032 Ryanodine receptor RyrDomainDomain
IPR003877 SPRY domainDomainDomain
IPR005821 Ion transport domainDomainDomain
IPR009460 Ryanodine Receptor TM 4-6DomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR013333 Ryanodine receptorFamilyFamily
IPR013662 RyR/IP3R Homology associated domainDomainDomain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptorDomainDomain
IPR016093 MIR motifDomainDomain
IPR035761 Ryanodine receptor, SPRY domain 1DomainDomain
IPR035762 Ryanodine receptor, SPRY domain 3DomainDomain
IPR035764 Ryanodine receptor, SPRY domain 2DomainDomain
IPR035910 RyR/IP3 receptor binding core, RIH domain superfamilyFamilyHomologous superfamily
IPR036300 Mir domain superfamilyFamilyHomologous superfamily
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01195 FlecainideDrugbanksmall molecule
DB09085 TetracaineDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
RYR2_HUMANSMAD5_HUMANBioGRID, HPRD, MINT15231748 details
RYR2_HUMANMDM2_HUMANBioGRID, IntAct20195357 details
RYR2_HUMANFKB1A_HUMANHPIDb11237759 details
RYR2_HUMANFKB1B_HUMANbhf-ucl, BioGRID, HPIDb, HPRD, IntAct10830164 11237759 12443530 12446682 21262961 23233753 details
RYR2_HUMANKAPCA_HUMANbhf-ucl, BioGRID, HPRD10830164 details
RYR2_HUMANAKAP6_HUMANbhf-ucl, BioGRID, HPRD10830164 11352932 details
RYR2_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
RYR2_HUMANHOME1_HUMANBioGRID, HPRD12887973 details
RYR2_HUMANKAPCG_HUMANBioGRID10830164 details
RYR2_HUMANKAPCB_HUMANBioGRID10830164 details
RYR2_HUMANRYR2_HUMANBioGRID10830164 14722100 21262961 25411383 details
RYR2_HUMANRYR1_HUMANBioGRID, HPRD12213830 14722100 details
RYR2_HUMANCAC1C_HUMANBioGRID, HPRD11576544 details
RYR2_HUMANCALM1_HUMANBioGRID23040497 26164367 details
RYR2_HUMANCALM2_HUMANBioGRID23040497 26164367 details
RYR2_HUMANCALM3_HUMANBioGRID23040497 26164367 details
RYR2_HUMANPSN1_HUMANBioGRID24029002 details
RYR2_HUMANKCC2D_HUMANDIP20479242 details
RYR2_HUMANBIN1_HUMANIntAct31413325 details
RYR2_HUMANKAP2_HUMANBioGRID, HPRD10830164 details
RYR2_HUMANKAP3_HUMANBioGRID10830164 details
RYR2_HUMANPP1A_HUMANBioGRID10830164 details
RYR2_HUMANPP1B_HUMANBioGRID10830164 details
RYR2_HUMANPP1G_HUMANBioGRID10830164 details
RYR2_HUMANRYR3_HUMANBioGRID, HPRD12213830 details
RYR2_HUMANSORCN_HUMANBioGRID, HPRD7592856 details
RYR2_HUMANTERF1_HUMANBioGRID20811636 details
RYR2_HUMANTERF2_HUMANBioGRID20811636 details
RYR2_HUMANITPR1_HUMANHPRD12754204 details