Entity Details

Primary name IOD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92813
EntryNameIOD2_HUMAN
FullNameType II iodothyronine deiodinase
TaxID9606
Evidenceevidence at protein level
Length273
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDIO2

GO terms

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GOName
GO:0001514 selenocysteine incorporation
GO:0004800 thyroxine 5'-deiodinase activity
GO:0005886 plasma membrane
GO:0006590 thyroid hormone generation
GO:0008430 selenium binding
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031625 ubiquitin protein ligase binding
GO:0033798 thyroxine 5-deiodinase activity
GO:0042403 thyroid hormone metabolic process
GO:0042404 thyroid hormone catabolic process
GO:0042446 hormone biosynthetic process
GO:0050873 brown fat cell differentiation
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000643 Iodothyronine deiodinaseFamilyFamily
IPR008261 Iodothyronine deiodinase, active siteSiteActive site
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09100 Thyroid, porcineDrugbankbiotech