Entity Details

Primary name BAD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92934
EntryNameBAD_HUMAN
FullNameBcl2-associated agonist of cell death
TaxID9606
Evidenceevidence at protein level
Length168
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesBAD

GO terms

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GOName
GO:0001836 release of cytochrome c from mitochondria
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0005543 phospholipid binding
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006007 glucose catabolic process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007283 spermatogenesis
GO:0008289 lipid binding
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009749 response to glucose
GO:0010508 positive regulation of autophagy
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0019050 suppression by virus of host apoptotic process
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0021987 cerebral cortex development
GO:0030346 protein phosphatase 2B binding
GO:0032024 positive regulation of insulin secretion
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0033133 positive regulation of glucokinase activity
GO:0033574 response to testosterone
GO:0034201 response to oleic acid
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043200 response to amino acid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043422 protein kinase B binding
GO:0044342 type B pancreatic cell proliferation
GO:0045471 response to ethanol
GO:0045579 positive regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045862 positive regulation of proteolysis
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046931 pore complex assembly
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051384 response to glucocorticoid
GO:0051592 response to calcium ion
GO:0060139 positive regulation of apoptotic process by virus
GO:0071247 cellular response to chromate
GO:0071260 cellular response to mechanical stimulus
GO:0071316 cellular response to nicotine
GO:0071396 cellular response to lipid
GO:0071456 cellular response to hypoxia
GO:0071889 14-3-3 protein binding
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901216 positive regulation of neuron death
GO:1901423 response to benzene
GO:1902220 positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1904710 positive regulation of granulosa cell apoptotic process
GO:2000078 positive regulation of type B pancreatic cell development
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR018868 Bcl2-associated agonist of cell deathFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB12340 NavitoclaxDrugbanksmall molecule

Interactions

58 interactions

InteractorPartnerSourcesPublicationsLink
BAD_HUMANB2CL1_HUMANBioGRID, HPRD, I2D, IntAct, MINT10611223 10620799 11077446 11206074 11483855 11494146 11583631 12115603 12137781 15131699 15694340 15705582 15721256 16697956 18628207 19427857 19667065 20603619 20837658 21988832 25241761 25416956 26186194 26264872 26871637 27684187 28514442 29997244 31467278 31515488 31980649 32296183 32814053 7834748 9305851 9388232 9389483 9824152 details
BAD_HUMANBCL2_HUMANBioGRID, HPRD, IntAct, MINT10611223 11483855 15694340 15849194 15990872 16697956 17446862 19168699 20603619 7834748 9305851 9388232 9463381 details
BAD_HUMANB2CL2_HUMANBioGRID, DIP, HPRD, IntAct10381646 11483855 12115603 15694340 16697956 20603619 22000515 32296183 details
BAD_HUMAN1433S_HUMANBioGRID, HPRD, IntAct, MINT11697890 16189514 20005908 20179209 21988832 31980649 details
BAD_HUMANEWS_HUMANBioGRID, HPRD, IntAct16189514 details
BAD_HUMANBNI3L_HUMANIntAct9973195 details
BAD_HUMANPP1A_HUMANBioGRID, HPRD, IntAct10811615 17274640 details
BAD_HUMANGRB2_HUMANIntAct17474147 details
BAD_HUMAN1433F_HUMANBioGRID, HPRD, IntAct11697890 17979178 21988832 28514442 31980649 9369453 details
BAD_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT11410287 11526496 11697890 17389761 19427857 19667065 20936779 21076048 21988832 23397142 25266655 25770209 28514442 31980649 details
BAD_HUMAN1433E_HUMANBioGRID, HPRD, IntAct11697890 17979178 20936779 21988832 31980649 9369453 details
BAD_HUMAN1433G_HUMANBioGRID, HPRD, IntAct10880354 20936779 28514442 31980649 details
BAD_HUMANCDN1A_HUMANBioGRID, IntAct21988832 details
BAD_HUMANKEAP1_HUMANBioGRID, IntAct21988832 details
BAD_HUMANCR3L3_HUMANBioGRID, IntAct21988832 details
BAD_HUMANPRDX2_HUMANBioGRID, IntAct21988832 details
BAD_HUMAN1433T_HUMANBioGRID, HPRD, IntAct10611223 11697890 15280438 15694340 21988832 28514442 31980649 8929531 9369453 details
BAD_HUMANSTEA3_HUMANBioGRID, IntAct21988832 details
BAD_HUMANSUMO2_HUMANBioGRID, MINT21900206 details
BAD_HUMAN1433B_HUMANBioGRID, HPRD, IntAct, MINT11697890 21900206 24255178 28514442 31980649 9369453 details
BAD_HUMANAKT1_HUMANBioGRID, HPRD, IntAct10358075 11500364 11994280 15722337 15998799 19667065 23085457 25241761 9381178 details
BAD_HUMANRAF1_HUMANBioGRID, HPRD, IntAct15849194 19667065 23397142 25241761 8929531 8929532 details
BAD_HUMANACTN2_HUMANBioGRID, IntAct32296183 details
BAD_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
BAD_HUMANKAPCA_HUMANBioGRID, HPRD, IntAct10837486 10880354 10949026 11500364 12931191 19667065 31980649 details
BAD_HUMANCAN1_HUMANIntAct32814053 details
BAD_HUMANA4_HUMANIntAct32814053 details
BAD_HUMANB2LA1_HUMANBioGRID, HPRD10381646 11483855 15694340 details
BAD_HUMANMCL1_HUMANBioGRID, HPRD10579309 10837489 11483855 15694340 details
BAD_HUMANKPCI_HUMANBioGRID15705582 details
BAD_HUMANPIM2_HUMANBioGRID, HPRD12954615 details
BAD_HUMANS10AA_HUMANBioGRID, HPRD9369453 details
BAD_HUMANKS6A1_HUMANBioGRID, HPRD10521512 10837486 10880354 10949026 11500364 12897128 9381178 details
BAD_HUMANKS6A5_HUMANBioGRID, HPRD10880354 11500364 details
BAD_HUMANPAK1_HUMANBioGRID, HPRD10611223 15784622 15849194 16413544 19667065 details
BAD_HUMANBRAF_HUMANBioGRID19667065 details
BAD_HUMANARAF_HUMANBioGRID19667065 details
BAD_HUMANPIM1_HUMANBioGRID, HPRD16403219 28620180 details
BAD_HUMANHRK_HUMANHPRD11483855 details
BAD_HUMANB2L11_HUMANMINT19427863 details
BAD_HUMANBAX_HUMANBioGRID, MINT17274640 19427863 details
BAD_HUMANCISD2_HUMANMINT20010695 details
BAD_HUMANWNK1_HUMANIntAct20936779 details
BAD_HUMANMK08_HUMANHPRD, IntAct14967141 23397142 details
BAD_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
BAD_HUMANSYUA_HUMANBioGRID, HPRD, IntAct10407019 15978696 31980649 details
BAD_HUMANGIMA5_HUMANBioGRID16509771 details
BAD_HUMANKPCD1_HUMANBioGRID20179209 details
BAD_HUMANKPCE_HUMANBioGRID20179209 details
BAD_HUMANBECN1_HUMANBioGRID28518135 details
BAD_HUMANULK1_HUMANBioGRID28518135 details
BAD_HUMANKS6A2_HUMANHPRD10521512 10837486 10880354 10949026 12897128 9381178 details
BAD_HUMANWASF1_HUMANHPRD12931191 details
BAD_HUMANB2L10_HUMANHPRD11278245 9878060 details
BAD_HUMANPAK5_HUMANHPRD10521512 10837486 10880354 12897128 9381178 details
BAD_HUMANPP2BA_HUMANHPRD10195903 details
BAD_HUMANKS6A3_HUMANHPRD11544290 details
BAD_HUMANPIM3_HUMANHPRD16403219 details