Entity Details

Primary name CHK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14757
EntryNameCHK1_HUMAN
FullNameSerine/threonine-protein kinase Chk1
TaxID9606
Evidenceevidence at protein level
Length476
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCHEK1

GO terms

Show/Hide Table
GOName
GO:0018107 peptidyl-threonine phosphorylation
GO:0106311 protein threonine kinase activity
GO:0035402 histone kinase activity (H3-T11 specific)
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0019904 protein domain specific binding
GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0048096 chromatin-mediated maintenance of transcription
GO:0106310 protein serine kinase activity
GO:0045787 positive regulation of cell cycle
GO:0046602 regulation of mitotic centrosome separation
GO:0000077 DNA damage checkpoint signaling
GO:0005615 extracellular space
GO:0006281 DNA repair
GO:0004672 protein kinase activity
GO:0006915 apoptotic process
GO:0006260 DNA replication
GO:0044818 mitotic G2/M transition checkpoint
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0071260 cellular response to mechanical stimulus
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
GO:0070317 negative regulation of G0 to G1 transition
GO:0005654 nucleoplasm
GO:0032991 protein-containing complex
GO:0000794 condensed nuclear chromosome
GO:0006975 DNA damage induced protein phosphorylation
GO:0035556 intracellular signal transduction
GO:0045839 negative regulation of mitotic nuclear division
GO:2000615 regulation of histone H3-K9 acetylation
GO:0000785 chromatin
GO:0005524 ATP binding
GO:0006974 cellular response to DNA damage stimulus
GO:1901796 regulation of signal transduction by p53 class mediator
GO:0006468 protein phosphorylation
GO:0090399 replicative senescence
GO:0004674 protein serine/threonine kinase activity
GO:0005634 nucleus

Subcellular Location

Show/Hide Table
Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR034670 Checkpoint kinase 1, catalytic domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB05149 XL844Drugbanksmall molecule
DB06486 EnzastaurinDrugbanksmall molecule
DB06852 CHIR-124Drugbanksmall molecule
DB06876 N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDEDrugbanksmall molecule
DB07025 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONEDrugbanksmall molecule
DB07034 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACIDDrugbanksmall molecule
DB07037 (2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OLDrugbanksmall molecule
DB07038 2-(cyclohexylamino)benzoic acidDrugbanksmall molecule
DB07075 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILEDrugbanksmall molecule
DB07078 (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONEDrugbanksmall molecule
DB07158 5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONEDrugbanksmall molecule
DB07213 (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOLDrugbanksmall molecule
DB07228 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREADrugbanksmall molecule
DB07243 (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATEDrugbanksmall molecule
DB07311 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONEDrugbanksmall molecule
DB07314 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREADrugbanksmall molecule
DB07320 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACIDDrugbanksmall molecule
DB07336 4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOLDrugbanksmall molecule
DB07647 (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OLDrugbanksmall molecule
DB07648 (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOLDrugbanksmall molecule
DB07653 N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINEDrugbanksmall molecule
DB07654 (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETICDrugbanksmall molecule
DB07655 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONEDrugbanksmall molecule
DB07959 3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLEDrugbanksmall molecule
DB08392 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOLDrugbanksmall molecule
DB08393 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOLDrugbanksmall molecule
DB08683 REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONEDrugbanksmall molecule
DB08774 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamineDrugbanksmall molecule
DB08776 N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDEDrugbanksmall molecule
DB08777 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONEDrugbanksmall molecule
DB08778 [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanoneDrugbanksmall molecule
DB08779 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-olDrugbanksmall molecule
DB08780 6-MORPHOLIN-4-YL-9H-PURINEDrugbanksmall molecule
DB08781 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

106 interactions

InteractorPartnerSourcesPublicationsLink
CHK1_HUMANCSK2B_HUMANHPRD, MINT12902976 15225637 details
CHK1_HUMANMDM4_HUMANBioGRID, HPRD, MINT16163388 16511572 details
CHK1_HUMANP53_HUMANBioGRID, HPRD, MINT10673501 11551930 11709713 11896572 12756247 15364958 16511572 9765199 details
CHK1_HUMANMPIP3_HUMANBioGRID, HPRD, IntAct, UniProt10557092 10681541 11016625 11333986 11390642 11551930 11836499 12660173 15705874 16330544 16705183 17035231 19330022 29735693 32357935 9278511 9278512 details
CHK1_HUMANAATF_HUMANHPRD, IntAct17157788 details
CHK1_HUMANMPIP1_HUMANBioGRID, HPRD, IntAct12399544 12676583 12759351 12963847 17292828 18480045 27432908 9278511 details
CHK1_HUMANRB_HUMANBioGRID, MINT17380128 details
CHK1_HUMANCLSPN_HUMANBioGRID, HPRD, IntAct12766152 16123041 16963448 23109433 details
CHK1_HUMANBRCA1_HUMANBioGRID, UniProt11836499 17380128 details
CHK1_HUMAN1433G_HUMANHPRD, MINT15324660 20639859 details
CHK1_HUMANPIGM_HUMANBioGRID, IntAct21988832 details
CHK1_HUMANERRFI_HUMANMINT22505024 details
CHK1_HUMANSMUF1_HUMANIntAct25249323 details
CHK1_HUMANATR_HUMANBioGRID, DIP, HPRD10608806 11252893 11390642 15775976 17686975 19330022 21566061 32357935 details
CHK1_HUMANCSK21_HUMANBioGRID12902976 15225637 details
CHK1_HUMANTP53B_HUMANBioGRID15364958 17984114 details
CHK1_HUMANXIAP_HUMANBioGRID, HPRD14759516 details
CHK1_HUMANATM_HUMANBioGRID, HPRD10608806 11252893 11390642 12676583 details
CHK1_HUMANPRKDC_HUMANBioGRID10608806 12756247 details
CHK1_HUMANMPIP2_HUMANBioGRID9278511 details
CHK1_HUMANMCPH1_HUMANBioGRID16783362 details
CHK1_HUMANXPO1_HUMANBioGRID12676962 details
CHK1_HUMANFANCE_HUMANBioGRID17296736 details
CHK1_HUMANUBP7_HUMANBioGRID21845734 25086746 25483066 26296656 31601781 32447346 details
CHK1_HUMANHS90A_HUMANBioGRID, HPRD16330544 21566061 22939624 details
CHK1_HUMANLATS2_HUMANBioGRID21118956 23886938 details
CHK1_HUMANMEPE_HUMANBioGRID19808933 details
CHK1_HUMANTLK1_HUMANBioGRID, HPRD12660173 12955071 details
CHK1_HUMANA4_HUMANBioGRID21832049 details
CHK1_HUMANTF65_HUMANBioGRID, HPRD15775976 details
CHK1_HUMANDTL_HUMANBioGRID23109433 23533280 details
CHK1_HUMANTOPB1_HUMANBioGRID17686975 details
CHK1_HUMANRD23A_HUMANBioGRID26296656 details
CHK1_HUMANUBA1_HUMANBioGRID26296656 details
CHK1_HUMANSAE2_HUMANBioGRID26296656 details
CHK1_HUMANFACD2_HUMANBioGRID19861535 details
CHK1_HUMANUBE2T_HUMANBioGRID28162934 details
CHK1_HUMANB2CL1_HUMANBioGRID22617334 details
CHK1_HUMANILKAP_HUMANBioGRID29371914 details
CHK1_HUMANATX3_HUMANBioGRID28180282 details
CHK1_HUMANCNTN2_HUMANBioGRID15107832 details
CHK1_HUMANUBP3_HUMANBioGRID29735693 details
CHK1_HUMANMCM2_HUMANBioGRID25049228 details
CHK1_HUMANMCM6_HUMANBioGRID25049228 details
CHK1_HUMANMCM7_HUMANBioGRID25049228 details
CHK1_HUMANBRCA2_HUMANBioGRID18317453 details
CHK1_HUMANAAPK1_HUMANBioGRID30428154 details
CHK1_HUMANTAU_HUMANBioGRID20159774 details
CHK1_HUMANFZR1_HUMANBioGRID32345958 details
CHK1_HUMANTRAF4_HUMANBioGRID32357935 details
CHK1_HUMANHDAC6_HUMANBioGRID33020410 details
CHK1_HUMANHS90B_HUMANIntAct16330544 22939624 details
CHK1_HUMANCUL1_HUMANBioGRID, HPRD, MINT16137618 17290223 19808933 23109433 30428154 details
CHK1_HUMANTIM_HUMANBioGRID, HPRD, IntAct15798197 details
CHK1_HUMAN1433B_HUMANMINT20639859 details
CHK1_HUMAN1433Z_HUMANMINT20639859 details
CHK1_HUMANATRIP_HUMANMINT20639859 details
CHK1_HUMANRFA2_HUMANMINT20639859 details
CHK1_HUMANMEN1_HUMANBioGRID, MINT20969866 details
CHK1_HUMANRAD51_HUMANBioGRID, HPRD, UniProt15665856 22665067 details
CHK1_HUMANKAT5_HUMANIntAct22863007 details
CHK1_HUMANCE164_HUMANIntAct22863007 details
CHK1_HUMANSRSF2_HUMANIntAct22863007 details
CHK1_HUMANKSR1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANSPD2A_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANIF4E2_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANSRGP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANGGYF1_HUMANIntActunassigned1312 details
CHK1_HUMANDEN1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANKI13B_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANLRFN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANZBT21_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANKCTD3_HUMANBioGRID, IntAct27173435 unassigned1312 details
CHK1_HUMANMSH2_HUMANBioGRID15647386 details
CHK1_HUMAN1433S_HUMANBioGRID11896572 details
CHK1_HUMANCDN1A_HUMANBioGRID11896572 details
CHK1_HUMANBLM_HUMANBioGRID, HPRD15364958 details
CHK1_HUMANXRCC6_HUMANBioGRID, HPRD12756247 details
CHK1_HUMANXRCC5_HUMANBioGRID12756247 details
CHK1_HUMANMSH6_HUMANBioGRID20029092 details
CHK1_HUMANDPOLA_HUMANBioGRID19177015 details
CHK1_HUMANPCNA_HUMANBioGRID18448427 details
CHK1_HUMANDNMT1_HUMANBioGRID17991895 20940144 details
CHK1_HUMANDDB1_HUMANBioGRID19276361 23109433 25024738 28192407 details
CHK1_HUMANCUL4A_HUMANBioGRID, HPRD16137618 19276361 19808933 23109433 details
CHK1_HUMANFEM1B_HUMANBioGRID19330022 details
CHK1_HUMANNEK2_HUMANBioGRID15311285 details
CHK1_HUMANBTG3_HUMANBioGRID23533280 29735693 details
CHK1_HUMANSETMR_HUMANBioGRID25024738 details
CHK1_HUMANZEB1_HUMANBioGRID25086746 details
CHK1_HUMANNFAC1_HUMANBioGRID27637333 details
CHK1_HUMANNFAC2_HUMANBioGRID27637333 details
CHK1_HUMANFBX6_HUMANBioGRID28180282 details
CHK1_HUMANH31_HUMANBioGRID29760279 details
CHK1_HUMANMCM3_HUMANBioGRID25049228 details
CHK1_HUMANMCM4_HUMANBioGRID25049228 details
CHK1_HUMANMCM5_HUMANBioGRID25049228 details
CHK1_HUMANCDC45_HUMANBioGRID25049228 details
CHK1_HUMANPSF1_HUMANBioGRID25049228 details
CHK1_HUMANFBW1A_HUMANBioGRID30428154 details
CHK1_HUMANNFKB1_HUMANBioGRID33024116 details
CHK1_HUMANUBB_HUMANHPRD16137618 details
CHK1_HUMANSMAD4_HUMANHPRD15761153 details
CHK1_HUMANIKKA_HUMANHPRD17962807 details
CHK1_HUMANAKT1_HUMANHPRD12062056 details