Entity Details

Primary name TR10B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14763
EntryNameTR10B_HUMAN
FullNameTumor necrosis factor receptor superfamily member 10B
TaxID9606
Evidenceevidence at protein level
Length440
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesTNFRSF10B

GO terms

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GOName
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0034976 response to endoplasmic reticulum stress
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0036463 TRAIL receptor activity
GO:0038023 signaling receptor activity
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045569 TRAIL binding
GO:0050900 leukocyte migration
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071260 cellular response to mechanical stimulus
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR020465 Tumour necrosis factor receptor 10FamilyFamily
IPR034024 Tumor necrosis factor receptor 10, N-terminalDomainDomain
IPR034029 Tumour necrosis factor receptor 10A/B, death domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB05895 HGS-TR2JDrugbankbiotech
DB06599 LexatumumabDrugbankbiotech

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
TR10B_HUMANTNF10_HUMANBioGRID, HPRD, IntAct, MINT10542098 10549288 10894160 11094155 16554480 19427028 19432816 20097879 20103630 21459798 21525171 21822306 22266862 22585859 23678861 25551360 9311998 9325248 details
TR10B_HUMANCASP8_HUMANBioGRID, HPRD, IntAct11940602 12218097 15388581 15659383 17047155 19343040 19432816 20103630 23142077 25043603 26186194 28514442 28972304 31443721 32313199 9325248 details
TR10B_HUMANASPH_HUMANBioGRID, IntAct32296183 details
TR10B_HUMANMUC1_HUMANBioGRID, IntAct32296183 details
TR10B_HUMANZDH15_HUMANBioGRID, IntAct32296183 details
TR10B_HUMANTIM50_HUMANBioGRID15044455 details
TR10B_HUMANTMM31_HUMANBioGRID32296183 details
TR10B_HUMANCDC42_HUMANBioGRID31478661 details
TR10B_HUMANARAP1_HUMANIntAct18165900 details
TR10B_HUMANTR10A_HUMANBioGRID, HPRD, IntAct15388581 16319225 19427028 28514442 29795330 9430228 details
TR10B_HUMANFADD_HUMANBioGRID, HPRD, IntAct11940602 15388581 15659383 23142077 25043603 26186194 28514442 28972304 31443721 32313199 9430227 details
TR10B_HUMANRAC1_HUMANIntAct25843002 details
TR10B_HUMANBID_HUMANBioGRID15659383 details
TR10B_HUMANEZRI_HUMANBioGRID15659383 details
TR10B_HUMANTNR6_HUMANBioGRID15659383 details
TR10B_HUMANTNFL6_HUMANBioGRID15659383 details
TR10B_HUMANMK08_HUMANBioGRID15659383 details
TR10B_HUMANMOES_HUMANBioGRID15659383 details
TR10B_HUMANCASPA_HUMANBioGRID15659383 9325248 details
TR10B_HUMANRHOA_HUMANBioGRID15659383 details
TR10B_HUMANGDIR1_HUMANBioGRID15659383 details
TR10B_HUMANTNR1A_HUMANBioGRID15659383 details
TR10B_HUMANCFLAR_HUMANBioGRID, HPRD11193041 11940602 19343040 23142077 32313199 9325248 details
TR10B_HUMANTRADD_HUMANBioGRID, HPRD9430227 details
TR10B_HUMANRIPK1_HUMANBioGRID, HPRD22585859 32313199 9430227 details
TR10B_HUMANCBL_HUMANBioGRID19932172 28972304 details
TR10B_HUMANITCH_HUMANBioGRID19808964 details
TR10B_HUMANTNAP3_HUMANBioGRID22585859 details
TR10B_HUMANTRAF2_HUMANBioGRID22585859 23142077 32313199 details
TR10B_HUMANCUL3_HUMANBioGRID23142077 32313199 details
TR10B_HUMANCBLB_HUMANBioGRID28972304 details
TR10B_HUMANCAV1_HUMANBioGRID19432816 details
TR10B_HUMANRN183_HUMANBioGRID31889078 details
TR10B_HUMANCUL1_HUMANBioGRID32313199 details
TR10B_HUMANSKP2_HUMANBioGRID32313199 details
TR10B_HUMANSKP1_HUMANBioGRID32313199 details
TR10B_HUMANRBX1_HUMANBioGRID32313199 details
TR10B_HUMANMADD_HUMANHPRD15208670 details
TR10B_HUMANTR10D_HUMANHPRD16319225 details