Entity Details

Primary name PANX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96RD7
EntryNamePANX1_HUMAN
FullNamePannexin-1
TaxID9606
Evidenceevidence at protein level
Length426
SequenceStatuscomplete
DateCreated2002-01-23
DateModified2021-06-02

Ontological Relatives

GenesPANX1

GO terms

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GOName
GO:0002020 protease binding
GO:0002931 response to ischemia
GO:0005102 signaling receptor binding
GO:0005198 structural molecule activity
GO:0005243 gap junction channel activity
GO:0005262 calcium channel activity
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0007267 cell-cell signaling
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0022829 wide pore channel activity
GO:0022840 leak channel activity
GO:0032059 bleb
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032991 protein-containing complex
GO:0033198 response to ATP
GO:0044325 transmembrane transporter binding
GO:0048477 oogenesis
GO:0051015 actin filament binding
GO:0097110 scaffold protein binding

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000990 InnexinFamilyFamily
IPR039099 PannexinFamilyFamily

Diseases

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Disease IDSourceNameDescription
618550 OMIMOocyte maturation defect 7 (OOMD7)An autosomal dominant infertility disorder due to oocyte degeneration and death, which may occur before or after fertilization. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01032 ProbenecidDrugbanksmall molecule