Entity Details

Primary name TBX3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15119
EntryNameTBX3_HUMAN
FullNameT-box transcription factor TBX3
TaxID9606
Evidenceevidence at protein level
Length743
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesTBX3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001216 DNA-binding transcription activator activity
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0001568 blood vessel development
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001947 heart looping
GO:0003151 outflow tract morphogenesis
GO:0003167 atrioventricular bundle cell differentiation
GO:0003205 cardiac chamber development
GO:0003272 endocardial cushion formation
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007417 central nervous system development
GO:0007569 cell aging
GO:0008284 positive regulation of cell population proliferation
GO:0008595 anterior/posterior axis specification, embryo
GO:0009887 animal organ morphogenesis
GO:0010159 specification of animal organ position
GO:0019827 stem cell population maintenance
GO:0021761 limbic system development
GO:0030539 male genitalia development
GO:0030540 female genitalia development
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030879 mammary gland development
GO:0032275 luteinizing hormone secretion
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0036302 atrioventricular canal development
GO:0042733 embryonic digit morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045662 negative regulation of myoblast differentiation
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046884 follicle-stimulating hormone secretion
GO:0048332 mesoderm morphogenesis
GO:0051145 smooth muscle cell differentiation
GO:0060021 roof of mouth development
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060412 ventricular septum morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060596 mammary placode formation
GO:0060923 cardiac muscle cell fate commitment
GO:0060931 sinoatrial node cell development
GO:0072105 ureteric peristalsis
GO:0090398 cellular senescence
GO:1905072 cardiac jelly development
GO:1905222 atrioventricular canal morphogenesis
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis
GO:2000648 positive regulation of stem cell proliferation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001699 Transcription factor, T-boxFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR018186 Transcription factor, T-box, conserved siteSiteConserved site
IPR022582 Transcription factor, T-box, region of unknown functionDomainDomain
IPR036960 T-box superfamilyFamilyHomologous superfamily

Diseases

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