Entity Details

Primary name EGLN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9GZT9
EntryNameEGLN1_HUMAN
FullNameEgl nine homolog 1
TaxID9606
Evidenceevidence at protein level
Length426
SequenceStatuscomplete
DateCreated2003-06-16
DateModified2021-06-02

Ontological Relatives

GenesEGLN1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008198 ferrous iron binding
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019899 enzyme binding
GO:0031418 L-ascorbic acid binding
GO:0031543 peptidyl-proline dioxygenase activity
GO:0031545 peptidyl-proline 4-dioxygenase activity
GO:0032364 oxygen homeostasis
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045765 regulation of angiogenesis
GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
GO:0071731 response to nitric oxide

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002893 Zinc finger, MYND-typeDomainDomain
IPR005123 Oxoglutarate/iron-dependent dioxygenaseDomainDomain
IPR006620 Prolyl 4-hydroxylase, alpha subunitDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00126 Ascorbic acidDrugbanksmall molecule
DB01592 IronDrugbanksmall molecule
DB04847 RoxadustatDrugbanksmall molecule
DB07112 N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINEDrugbanksmall molecule
DB08687 FG-2216Drugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
EGLN1_HUMANHIF1A_HUMANBioGRID, DIP, HPRD, IntAct, MINT15474027 15721254 16155211 16407130 16511565 17069766 17353276 17442832 18063574 18264140 19604478 20724477 20840591 22946054 23413029 24681946 25361009 25974097 26611735 27563096 29279301 31763849 details
EGLN1_HUMANOS9_HUMANBioGRID, HPRD, IntAct15721254 21559462 details
EGLN1_HUMANVHL_HUMANBioGRID, IntAct17986458 22286099 26215701 details
EGLN1_HUMANRASK_HUMANBioGRID, IntAct21988832 details
EGLN1_HUMANZN281_HUMANBioGRID, IntAct21988832 details
EGLN1_HUMANFKBP8_HUMANBioGRID, IntAct17353276 19147576 19546213 21559462 23413029 24711448 27770548 31763849 32877691 details
EGLN1_HUMANEPAS1_HUMANBioGRID, HPRD, IntAct15474027 16407130 17353276 19147576 19208626 23275444 30487161 31763849 details
EGLN1_HUMANSDCB1_HUMANMINT26787460 details
EGLN1_HUMANING4_HUMANBioGRID, HPRD15897452 17848618 details
EGLN1_HUMANH31_HUMANBioGRID19624289 details
EGLN1_HUMANSRC_HUMANBioGRID21335603 details
EGLN1_HUMANMAGAB_HUMANBioGRID19147576 details
EGLN1_HUMANPLD1_HUMANBioGRID25361009 details
EGLN1_HUMANHS90A_HUMANBioGRID23413029 24711448 details
EGLN1_HUMANHS90B_HUMANBioGRID23413029 24711448 31763849 details
EGLN1_HUMANSH3K1_HUMANBioGRID31142511 details
EGLN1_HUMANKPYM_HUMANBioGRID, IntAct21620138 details
EGLN1_HUMANRPB1_HUMANBioGRID18285459 details
EGLN1_HUMANOSR1_HUMANBioGRID15084514 16511565 details
EGLN1_HUMANSIAH2_HUMANBioGRID15210114 16958618 details
EGLN1_HUMANEGLN1_HUMANBioGRID16958618 details
EGLN1_HUMANEGLN3_HUMANBioGRID16958618 31763849 details
EGLN1_HUMANSPY2_HUMANBioGRID22006925 details
EGLN1_HUMANLIMD1_HUMANBioGRID22286099 26215701 details
EGLN1_HUMANMAGA9_HUMANBioGRID19147576 details
EGLN1_HUMANPLD2_HUMANBioGRID26611735 details
EGLN1_HUMANPHLD_HUMANBioGRID26680696 details
EGLN1_HUMANRHBT3_HUMANBioGRID26215701 details
EGLN1_HUMANTEBP_HUMANBioGRID23413029 24711448 31763849 details
EGLN1_HUMANFKBP4_HUMANBioGRID23413029 details
EGLN1_HUMANAKT1_HUMANBioGRID27563096 details
EGLN1_HUMANAKT2_HUMANBioGRID27563096 details
EGLN1_HUMANMTG16_HUMANBioGRID25974097 details
EGLN1_HUMANRUNX3_HUMANBioGRID23542169 details
EGLN1_HUMANKEAP1_HUMANBioGRID31763849 details
EGLN1_HUMANBRD4_HUMANBioGRID31239290 details
EGLN1_HUMANTET2_HUMANBioGRID32963106 details
EGLN1_HUMANTET3_HUMANBioGRID32963106 details
EGLN1_HUMANHIF3A_HUMANHPRD15474027 details