Entity Details

Primary name P2Y12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H244
EntryNameP2Y12_HUMAN
FullNameP2Y purinoceptor 12
TaxID9606
Evidenceevidence at protein level
Length342
SequenceStatuscomplete
DateCreated2002-05-27
DateModified2021-06-02

Ontological Relatives

GenesP2RY12

GO terms

Show/Hide Table
GOName
GO:0001609 G protein-coupled adenosine receptor activity
GO:0001621 G protein-coupled ADP receptor activity
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007599 hemostasis
GO:0009897 external side of plasma membrane
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010700 negative regulation of norepinephrine secretion
GO:0016021 integral component of membrane
GO:0019722 calcium-mediated signaling
GO:0021808 cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
GO:0030030 cell projection organization
GO:0030032 lamellipodium assembly
GO:0030168 platelet activation
GO:0031224 intrinsic component of membrane
GO:0031253 cell projection membrane
GO:0033626 positive regulation of integrin activation by cell surface receptor linked signal transduction
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035585 calcium-mediated signaling using extracellular calcium source
GO:0043270 positive regulation of ion transport
GO:0043491 protein kinase B signaling
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044298 cell body membrane
GO:0045028 G protein-coupled purinergic nucleotide receptor activity
GO:0045596 negative regulation of cell differentiation
GO:0048678 response to axon injury
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0051924 regulation of calcium ion transport
GO:0070527 platelet aggregation
GO:0070588 calcium ion transmembrane transport
GO:0071318 cellular response to ATP
GO:0071805 potassium ion transmembrane transport
GO:0150063 visual system development
GO:1900029 positive regulation of ruffle assembly
GO:1904124 microglial cell migration
GO:1904139 regulation of microglial cell migration
GO:1904141 positive regulation of microglial cell migration

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR005394 P2Y12 purinoceptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00208 TiclopidineDrugbanksmall molecule
DB00374 TreprostinilDrugbanksmall molecule
DB00758 ClopidogrelDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01240 EpoprostenolDrugbanksmall molecule
DB05553 RegrelorDrugbanksmall molecule
DB06209 PrasugrelDrugbanksmall molecule
DB06350 ElinogrelDrugbanksmall molecule
DB06441 CangrelorDrugbanksmall molecule
DB08816 TicagrelorDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
P2Y12_HUMANP2Y12_HUMANDIP16835302 details
P2Y12_HUMANGNAI2_HUMANHPRD8554519 details