Entity Details

Primary name MRP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15438
EntryNameMRP3_HUMAN
FullNameATP-binding cassette sub-family C member 3
TaxID9606
Evidenceevidence at protein level
Length1527
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesABCC3

GO terms

Show/Hide Table
GOName
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0006855 drug transmembrane transport
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015164 glucuronoside transmembrane transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015432 ABC-type bile acid transporter activity
GO:0015721 bile acid and bile salt transport
GO:0015722 canalicular bile acid transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042908 xenobiotic transport
GO:0042910 xenobiotic transmembrane transporter activity
GO:0055085 transmembrane transport
GO:0071714 icosanoid transmembrane transporter activity
GO:0071716 leukotriene transport
GO:0150104 transport across blood-brain barrier

Subcellular Location

Show/Hide Table
Subcellular Location
Basolateral cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR005292 Multi drug resistance-associated proteinFamilyFamily
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00158 Folic acidDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00338 OmeprazoleDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00541 VincristineDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00950 FexofenadineDrugbanksmall molecule
DB00973 EzetimibeDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01011 MetyraponeDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB02659 Cholic AcidDrugbanksmall molecule
DB04348 Taurocholic acidDrugbanksmall molecule
DB05928 DovitinibDrugbanksmall molecule
DB08884 Gadoxetic acidSwissprotsmall molecule
DB11936 Bempedoic acidDrugbanksmall molecule
DB15719 Belantamab mafodotinDrugbankbiotech

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MRP3_HUMANMLH1_HUMANBioGRID, IntAct20706999 details