Entity Details

Primary name TIGAR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQ88
EntryNameTIGAR_HUMAN
FullNameFructose-2,6-bisphosphatase TIGAR
TaxID9606
Evidenceevidence at protein level
Length270
SequenceStatuscomplete
DateCreated2005-12-06
DateModified2021-06-02

Ontological Relatives

GenesTIGAR

GO terms

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GOName
GO:0002931 response to ischemia
GO:0004083 bisphosphoglycerate 2-phosphatase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0009410 response to xenobiotic stimulus
GO:0010332 response to gamma radiation
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0043069 negative regulation of programmed cell death
GO:0043456 regulation of pentose-phosphate shunt
GO:0045739 positive regulation of DNA repair
GO:0045820 negative regulation of glycolytic process
GO:0060576 intestinal epithelial cell development
GO:0071279 cellular response to cobalt ion
GO:0071456 cellular response to hypoxia
GO:1901215 negative regulation of neuron death
GO:1901525 negative regulation of mitophagy
GO:1902153 regulation of response to DNA damage checkpoint signaling
GO:1903301 positive regulation of hexokinase activity
GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active siteSiteActive site
IPR013078 Histidine phosphatase superfamily, clade-1FamilyFamily
IPR029033 Histidine phosphatase superfamilyFamilyHomologous superfamily

Diseases

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